SCHEMBL3394019

SCHEMBL3394019

CC1=C(C(=O)O)C(C)(c2ccc(Cl)c(Cl)c2)C(C(=O)O)=C(C)N1C

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 4/20 0.43
OPRM1 P35372 1/20 0.40
BACE1 P56817 1/20 0.39
TSHR P16473 1/20 0.39
NOTUM Q6P988 1/20 0.38
KMO O15229 1/20 0.37
SLC6A3 Q01959 2/20 0.36
CHRNA1 P02708 1/20 0.35
CHRNG P07510 1/20 0.35
CHRNB1 P11230 1/20 0.35
CHRNB2 P17787 1/20 0.35
SLC6A2 P23975 1/20 0.35
CHRNB4 P30926 1/20 0.35
SLC6A4 P31645 1/20 0.35
CHRNA3 P32297 1/20 0.35
CHRNA4 P43681 1/20 0.35
CHRND Q07001 1/20 0.35
GPR35 Q9HC97 1/20 0.35
SRD5A2 P31213 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4758043 0.75 CRHBP (0.40) NOTUM
SCHEMBL10860016 0.73 ALDH1A1 (0.43) TSHRGPR35
SCHEMBL4758575 0.70 OPRM1 (0.39) CCR2OPRM1TSHRNOTUMSLC6A3
SCHEMBL1779399 0.66 CCR2 (0.55) CCR2SLC6A3CHRNA1CHRNGCHRNB1
SCHEMBL1782801 0.66 CCR2 (0.62) CCR2SLC6A3CHRNA1CHRNGCHRNB1
SCHEMBL1780146 0.63 CCR2 (0.49) CCR2SLC6A3CHRNA1CHRNGCHRNB1
SCHEMBL1783190 0.63 CCR2 (0.46) CCR2TSHRSLC6A3CHRNA1CHRNG
SCHEMBL3394045 0.63 MEN1 (0.34) TSHR
Hydrochloric Acid SCHEMBL6167759 0.62 OPRM1 (0.68) OPRM1SLC6A3SLC6A2SLC6A4
SCHEMBL24281411 0.62 CCR2 (0.45) CCR2TSHRKMOSLC6A3CHRNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2229167-A1 MINERALOCORTICOID RECEPTOR MODULATORS Merck Sharp & Dohme Corp. (US) 2010-09-22 EP disclosed
WO-2009078934-A1 MINERALOCORTICOID RECEPTOR MODULATORS MERCK & CO., INC. (US) 2009-06-25 WO disclosed
WO-2008006070-A2 COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF ROSKAMP RESEARCH LLC (US) 2008-01-10 WO disclosed
EP-1858325-A2 COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS Roskamp Research LLC (US) 2007-11-28 EP disclosed
WO-2006074419-A2 COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS ROSKAMP RESEARCH LLC (US) 2006-07-13 WO disclosed