Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL354701 | 0.74 | HSD11B1 (0.39) | HSD11B1CYP2C9 | |
| SCHEMBL9063591 | 0.70 | ALDH1A1 (0.30) | — | |
| SCHEMBL4507439 | 0.69 | HSD11B1 (0.40) | HSD11B1 | |
| SCHEMBL31226476 | 0.66 | HSD11B1 (0.38) | HSD11B1 | |
| SCHEMBL339975 | 0.64 | MEN1 (0.40) | CYP2C9 | |
| SCHEMBL159996 | 0.63 | HSD11B1 (0.50) | HSD11B1CYP2C9 | |
| SCHEMBL22462244 | 0.63 | HSD11B1 (0.50) | HSD11B1CYP2C9 | |
| SCHEMBL19017773 | 0.63 | HSD11B1 (0.44) | HSD11B1CYP2C9 | |
| SCHEMBL21650459 | 0.63 | HSD11B1 (0.44) | HSD11B1CYP2C9 | |
| SCHEMBL22483779 | 0.63 | HSD11B1 (0.44) | HSD11B1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050119181-A1 | Hydrophobically-modified protein compositions and methods | BIOGEN IDEC INC. (US) | 2005-06-02 | — | — | US | claimed |
| EP-1036092-B1 | Hydrophobically-modified hedgehog protein compositions and methods | BIOGEN INC (US) | 2005-05-11 | — | — | EP | claimed |
| EP-1036092-A2 | HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS | BIOGEN, INC. (US) | 2000-09-20 | — | — | EP | claimed |
| WO-1999028343-A9 | HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS | BIOGEN INC (US) | 1999-10-14 | — | — | WO | claimed |
| WO-1999028343-A2 | HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS | BIOGEN, INC. (US) | 1999-06-10 | — | — | WO | claimed |
| EP-1646395-B1 | METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY | CURIS INC (US) | 2014-11-05 | — | — | EP | disclosed |
| US-20130085096-A1 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-04-04 | — | — | US | disclosed |
| US-20120269863-A1 | METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY | CURIS, INC. (US) | 2012-10-25 | — | — | US | disclosed |
| US-20120238500-A1 | REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | CURIS, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| US-8168178-B2 | Methods and compositions for regulating lymphocyte activity | CURIS, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-8097253-B2 | Methods for inhibiting angiogenesis | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2012-01-17 | — | — | US | disclosed |
| EP-2359842-A1 | Netrin-related compositions and uses | University of Utah Research Foundation (US) | 2011-08-24 | — | — | EP | disclosed |
| US-5888992-A | PROTEASE INHIBITOR; VIRICIDE | NARHEX LIMITED (HK) | 1999-03-30 | — | — | US | disclosed |
| WO-1999010004-A2 | REGULATION OF MUSCLE TISSUES BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | ONTOGENY, INC. (US) | 1999-03-04 | — | — | WO | disclosed |
| US-5801274-A | N- mercaptoacyl(amino acid or peptide)! compounds and S-lipophilic aliphatic carbonyl derivatives thereof as antihypertensives | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1998-09-01 | — | — | US | disclosed |
| US-5591891-A | PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-01-07 | — | — | US | disclosed |
| EP-0717736-A4 | POLAR-SUBSTITUTED HYDROCARBONS | NARHEX LTD (HK) | 1996-08-28 | — | — | EP | disclosed |
| EP-0717736-A1 | POLAR-SUBSTITUTED HYDROCARBONS | NARHEX LIMITED (HK) | 1996-06-26 | — | — | EP | disclosed |
| WO-1995007269-A1 | POLAR-SUBSTITUTED HYDROCARBONS | NARHEX LIMITED (HK) | 1995-03-16 | — | — | WO | disclosed |
| WO-1994017036-A1 | S-LIPOPHILIC ALIPHATIC CARBONYL [N-MERCAPTOACYL-(AMINO ACID OR PEPTIDE)] COMPOUNDS AS ANTIHYPERTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1994-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238500-A1 | REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | SHH, SMO, GLI1 | HSD11B1 4419/4885CYP2C9 4884/4885 |
| US-20130085096-A1 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | SHH, FGF1, HGF | HSD11B1 3964/4885CYP2C9 4877/4885 |
| US-20120269863-A1 | METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY | SHH, ICOS, SMO | HSD11B1 1713/4885CYP2C9 4493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.