SCHEMBL3395495

SCHEMBL3395495

Cc1cccc(I)c1-c1c(C)cccc1I

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.43
CYP1A2 P05177 1/20 0.43
TSHR P16473 2/20 0.42
ACHE P22303 2/20 0.42
CD44 P16070 1/20 0.42
ALDH1A1 P00352 4/20 0.41
CA1 P00915 3/20 0.41
CA2 P00918 3/20 0.41
CA7 P43166 3/20 0.41
CA9 Q16790 3/20 0.41
CYP3A4 P08684 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
GRIN2D O15399 1/20 0.36
GRIN3B O60391 1/20 0.36
GRIN1 Q05586 1/20 0.36
GRIN2A Q12879 1/20 0.36
GRIN2B Q13224 1/20 0.36
GRIN2C Q14957 1/20 0.36
GRIN3A Q8TCU5 1/20 0.36
SIGMAR1 Q99720 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22237885 0.83 SRC (0.36) CYP2A6CYP1A2TSHRACHECD44
SCHEMBL18938794 0.83 CYP1A2 (0.35) CYP2A6CYP1A2TSHRACHECD44
SCHEMBL1768471 0.83 MYC (0.42) CYP2A6CYP1A2TSHRACHECD44
SCHEMBL20072679 0.81 C1R (0.34) CYP2A6CYP1A2TSHRACHECD44
SCHEMBL22357733 0.81 CD44 (0.33) CYP2A6CYP1A2TSHRACHECD44
SCHEMBL17448425 0.81 TRPA1 (0.48) CYP1A2TSHRCD44ALDH1A1CA1
SCHEMBL24625660 0.79 MYC (0.48) CYP2A6CYP1A2TSHRACHECD44
SCHEMBL21730835 0.79 TDP2 (0.46) CYP2A6CYP1A2TSHRACHECD44
SCHEMBL10212401 0.78
SCHEMBL18938792 0.78 PARP1 (0.33) CYP2A6CYP1A2CD44ALDH1A1CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2251342-A1 FUSED RING COMPOUND, METHOD FOR PRODUCING THE SAME, POLYMER, ORGANIC THIN FILM CONTAINING THE COMPOUND AND/OR THE POLYMER, AND ORGANIC THIN FILM DEVICE AND ORGANIC THIN FILM TRANSISTOR EACH COMPRISING THE ORGANIC THIN FILM Osaka University (JP) 2010-11-17 EP disclosed
EP-2061755-A1 TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS XENON PHARMACEUTICALS INC. (CA) 2009-05-27 EP disclosed
US-20090069408-A1 TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS XENON PHARMACEUTICALS INC. (CA) 2009-03-12 US disclosed
US-20090069408-A1 TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS XENON PHARMACEUTICALS INC. (CA) 2009-03-12 US disclosed
WO-2008109840-A1 TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS XENON PHARMACEUTICALS INC. (CA) 2008-09-12 WO disclosed
EP-0889049-B1 Novel diarsine compounds HOFFMANN LA ROCHE (US) 2003-04-16 EP disclosed
US-6037479-A USEFUL IN ENANTIOSELECTIVE REACTIONS AND WHICH GIVE RISE TO IMPROVED OPTICAL YIELDS HOFFMAN-LA ROCHE INC. (US) 2000-03-14 US disclosed
EP-0647648-B1 Optically active phosphorus compounds HOFFMANN LA ROCHE (CH) 1999-03-10 EP disclosed
EP-0889049-A1 Novel diarsine compounds F. HOFFMANN-LA ROCHE AG (CH) 1999-01-07 EP disclosed
US-5516944-A ENANTIOMORPHS WITH PHOSPHINE GROUPS FOR FORMING METAL COMPLEXES HOFFMANN-LA ROCHE INC. (US) 1996-05-14 US disclosed
US-5514805-A ASSYMETRIC HYDROGENATION OF A PYRIDINECARBONYL COMPOUND, RHODIUM PHOSPHINE CATALYST HOFFMANN-LA ROCHE INC. (US) 1996-05-07 US disclosed
US-5508438-A Phosphorus compounds HOFFMANN-LA ROCHE INC. (US) 1996-04-16 US disclosed
EP-0647648-A1 Optically active phosphorus compounds F. HOFFMANN-LA ROCHE AG (CH) 1995-04-12 EP disclosed
US-5302738-A Chiral phosphines HOFFMANN-LA ROCHE INC. (US) 1994-04-12 US disclosed
US-5274125-A Chirale phosphines HOFFMANN-LA ROCHE INC. (US) 1993-12-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090069408-A1 TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS TFRC, SLC40A1, FECH CYP2A6 763/4885CYP1A2 313/4885TSHR 121/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.