SCHEMBL339565

SCHEMBL339565

O=C(Cn1nnc(C(F)(F)F)n1)c1cc(C(=O)O)n(-c2ncccc2Cl)n1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.33
TRPV1 Q8NER1 2/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
ALDH1A1 P00352 2/20 0.32
HPGD P15428 2/20 0.32
MARS1 P56192 1/20 0.32
KLKB1 P03952 1/20 0.31
SLC16A3 O15427 1/20 0.31
SLC16A1 P53985 1/20 0.31
CNR1 P21554 1/20 0.31
CNR2 P34972 1/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
NPC1 O15118 2/20 0.31
RAB9A P51151 2/20 0.31
CASP3 P42574 1/20 0.31
SENP8 Q96LD8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
OPRL1 P41146 1/20 0.31
RORC P51449 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL45069 0.87 RAB9A (0.39) ALDH1A1HPGDSMN1; SMN2NPC1RAB9A
SCHEMBL45281 0.87 TRPA1 (0.35) TRPA1TRPV1MEN1KMT2AALDH1A1
SCHEMBL2134837 0.85 NPC1 (0.35) TRPA1TRPV1MARS1SLC16A3SLC16A1
SCHEMBL2131820 0.84 RXRA (0.36) TRPA1TRPV1MEN1KMT2AKLKB1
SCHEMBL1697035 0.83 HPGD (0.35) TRPA1TRPV1MEN1KMT2AALDH1A1
SCHEMBL341466 0.83 ALDH1A1 (0.33) TRPA1TRPV1ALDH1A1KLKB1SLC16A3
SCHEMBL24287198 0.78 TRPA1 (0.34) TRPA1TRPV1ALDH1A1SLC16A3SLC16A1
SCHEMBL10118295 0.77 SLC2A1 (0.36) ALDH1A1SMN1; SMN2
SCHEMBL30388183 0.77 SCN9A (0.36) TRPA1TRPV1SLC16A3SLC16A1SMN1; SMN2
SCHEMBL2131814 0.77 ALDH1A1 (0.39) TRPA1TRPV1ALDH1A1SLC16A3SLC16A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582688-B1 ANTHRANILIC ACID DIAMIDE DERIVATIVES BAYER IP GMBH (DE) 2015-10-07 EP disclosed
US-8791139-B2 Anthranilic diamide derivatives BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
CN-103068813-A Anthranilic acid diamide derivatives BAYER CROPSCIENCE AG 2013-04-24 CN disclosed
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2012-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES DDT, QDPR, ANTXR2 TRPA1 1434/4885TRPV1 2761/4885MEN1 1583/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.