SCHEMBL3396230

SCHEMBL3396230

COCC(OC)C(N)=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14744183 0.81 DDAH1 (0.34)
SCHEMBL22090192 0.81 LMNA (0.38)
SCHEMBL28076701 0.81 DDAH1 (0.34)
SCHEMBL11019367 0.79 ALOX15 (0.36)
SCHEMBL1079583 0.77
SCHEMBL228308 0.77
SCHEMBL11964810 0.77
SCHEMBL21304164 0.77
SCHEMBL1697378 0.77
Hydrochloric Acid SCHEMBL2715572 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2245033-A1 PYRROLOPYRAZINE KINASE INHIBITORS F. Hoffmann-La Roche AG (CH) 2010-11-03 EP claimed
WO-2009106441-A1 PYRROLOPYRAZINE KINASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2009-09-03 WO claimed
US-5880158-A TREATMENT OF EPILEPSY AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS RESEARCH CORPORATION TECH., INC. (US) 1999-03-09 US claimed
WO-2018208847-A1 COMPOUNDS AND METHODS FOR TREATMENT OF PAIN FROM INFLAMMATORY BOWEL DISEASE ARENA PHARMACEUTICALS, INC. (US) 2018-11-15 WO disclosed
EP-2763990-A1 PYRROLOPYRAZINE KINASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2014-08-13 EP disclosed
WO-2013030138-A1 PYRROLOPYRAZINE KINASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2013-03-07 WO disclosed
US-5880158-A TREATMENT OF EPILEPSY AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS RESEARCH CORPORATION TECH., INC. (US) 1999-03-09 US disclosed
WO-1998013336-A1 PROPIONAMIDE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1998-04-02 WO disclosed
US-4536599-A HYDROLYZING THE NITRILE DERIVATIVE TO THE AMIDE USING AN ORGANIC QUATERNARY AMINE SALT CATALYST; EFFICIENCY SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1985-08-20 US disclosed
EP-0040896-B1 SYNTHESIS OF AMIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-04-25 EP disclosed
EP-0040896-A2 Synthesis of amides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1981-12-02 EP disclosed
EP-0008532-A1 Synthesis of amines SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1980-03-05 EP disclosed