SCHEMBL3396382

SCHEMBL3396382

Nc1nc(N)c2[nH]c(N)nc2n1

nearest known ligand 0.52

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PNP P00491 1/20 0.52
PDPK1 O15530 1/20 0.47
GDA Q9Y2T3 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3964705 0.79 PDPK1 (0.41) PDPK1GDA
SCHEMBL1251786 0.79
SCHEMBL5133438 0.77 ADORA2A (0.55) PDPK1GDA
SCHEMBL6424961 0.77 PNP (0.48) PNP
SCHEMBL2634662 0.77 NUDT1 (0.61) PDPK1GDA
SCHEMBL1766004 0.77 PDPK1 (0.44) PDPK1GDA
SCHEMBL6356987 0.77 PNP (0.54) PNP
SCHEMBL1705024 0.77 PDPK1 (0.44) PDPK1GDA
SCHEMBL4907123 0.77 PDPK1 (0.44) PDPK1GDA
SCHEMBL16513157 0.77 PDPK1 (0.44) PDPK1GDA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4680228-A2 OPHTHALMIC CREAM FORMULATIONS AND THEIR USES Glaukos Corporation (US) 2026-01-21 EP claimed
US-20240316028-A1 OPHTHALMIC CREAM FORMULATIONS AND THEIR USES GLAUKOS CORP (US) 2024-09-26 US claimed
WO-2024192323-A2 OPHTHALMIC CREAM FORMULATIONS AND THEIR USES GLAUKOS CORPORATION (US) 2024-09-19 WO claimed
WO-2019227847-A1 CHITOSAN-BASED IONIC CONDUCTIVE MATERIAL CONTAINING PURINE STRUCTURE AND PREPARATION METHOD THEREOF 华南理工大学 (CN) 2019-12-05 WO claimed
EP-4680228-A2 OPHTHALMIC CREAM FORMULATIONS AND THEIR USES Glaukos Corporation (US) 2026-01-21 EP disclosed
US-20240316028-A1 OPHTHALMIC CREAM FORMULATIONS AND THEIR USES GLAUKOS CORP (US) 2024-09-26 US disclosed
WO-2024192323-A2 OPHTHALMIC CREAM FORMULATIONS AND THEIR USES GLAUKOS CORPORATION (US) 2024-09-19 WO disclosed
CN-109036623-A A kind of cellulose base ion conductive material of purine-containing structure and preparation method thereof 华南理工大学 2018-12-18 CN disclosed
EP-2249874-A1 METHODS AND MEANS FOR TREATING DNA REPEAT INSTABILITY ASSOCIATED GENETIC DISORDERS ProSensa Holding BV (NL) 2010-11-17 EP disclosed
WO-2009099326-A1 METHODS AND MEANS FOR TREATING DNA REPEAT INSTABILITY ASSOCIATED GENETIC DISORDERS PROSENSA HOLDING BV (NL) 2009-08-13 WO disclosed
WO-2009079000-A1 IMIDAZOLOPYRIMIDINE MODULATORS OF TRPV1 JANSSEN PHARMACEUTICA N.V. (BE) 2009-06-25 WO disclosed
US-20050043268-A1 Inhibition of viruses MEDICAL RESEARCH COUNCIL (GB) 2005-02-24 US disclosed
EP-0286425-B1 Therapeutic nucleosides WELLCOME FOUND (GB) 1995-01-11 EP disclosed
US-5185437-A 6-substituted 2',3'-dideoxypurine nucleosides; treatment for human immunodeficiency virus and heptatis b virus BURROUGHS WELLCOME CO. (US) 1993-02-09 US disclosed
US-5068320-A 2-amino-6-(cyclopropylamino)purine-9-β-D-2',3'-dideoxyribofuranoside and its pharmaceutically acceptable salts BURROUGHS WELLCOME CO. (US) 1991-11-26 US disclosed
EP-0421819-A1 Therapeutic nucleosides THE WELLCOME FOUNDATION LIMITED (GB) 1991-04-10 EP disclosed
EP-0286425-A2 Therapeutic nucleosides THE WELLCOME FOUNDATION LIMITED (GB) 1988-10-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050043268-A1 Inhibition of viruses RNASE1, HNRNPA1, RNASEH1 PNP 132/4885PDPK1 4629/4885GDA 465/4885
US-20240316028-A1 OPHTHALMIC CREAM FORMULATIONS AND THEIR USES PDE12, TBXA2R, PDE6G PNP 2553/4885PDPK1 2635/4885GDA 4294/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.