Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 7/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 3/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3403000 | 0.92 | NPC1 (0.50) | MAPTNPC1HPGDTP53MEN1 | |
| SCHEMBL3400463 | 0.84 | PPARA (0.54) | MAPTNPC1HPGDLMNATP53 | |
| SCHEMBL3401033 | 0.82 | TARBP2 (0.49) | MAPTNPC1LMNAMEN1KMT2A | |
| SCHEMBL3399977 | 0.81 | TSHR (0.53) | MAPTNPC1HPGDLMNATP53 | |
| SCHEMBL3405206 | 0.81 | GLA (0.60) | MAPTNPC1HPGDLMNATP53 | |
| SCHEMBL3405796 | 0.80 | ALDH1A1 (0.48) | MAPTNPC1HPGDLMNATP53 | |
| SCHEMBL23957007 | 0.78 | HPGD (0.51) | MAPTNPC1HPGDLMNATP53 | |
| SCHEMBL25828324 | 0.77 | XDH (0.54) | MAPTNPC1HPGDLMNAMEN1 | |
| SCHEMBL23957002 | 0.77 | NPC1 (0.45) | MAPTNPC1HPGDTP53MEN1 | |
| SCHEMBL28297246 | 0.77 | CDC7 (0.71) | MAPTLMNAMEN1KMT2ATARBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |