Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 7/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 4/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3396720 | 0.92 | MAPT (0.56) | NPC1HPGDMAPTSMN1; SMN2TARBP2 | |
| SCHEMBL3405790 | 0.82 | TARBP2 (0.47) | MAPTTARBP2PPARAPPARDMEN1 | |
| SCHEMBL3400463 | 0.82 | PPARA (0.54) | NPC1HPGDMAPTSMN1; SMN2PPARA | |
| SCHEMBL3406028 | 0.81 | GLA (0.50) | NPC1HPGDMAPTTARBP2PPARA | |
| SCHEMBL3399977 | 0.79 | TSHR (0.53) | NPC1HPGDMAPTSMN1; SMN2PPARA | |
| SCHEMBL3401121 | 0.79 | AGER (0.47) | NPC1HPGDMAPTTP53 | |
| SCHEMBL3405796 | 0.78 | ALDH1A1 (0.48) | NPC1HPGDMAPTSMN1; SMN2PPARA | |
| SCHEMBL25828324 | 0.78 | XDH (0.54) | NPC1HPGDMAPTTARBP2MEN1 | |
| SCHEMBL13310379 | 0.78 | ACKR3 (0.50) | NPC1HPGDMAPTPPARAPPARD | |
| SCHEMBL23957007 | 0.76 | HPGD (0.51) | NPC1HPGDMAPTSMN1; SMN2PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |