Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TACR2 | P21452 | 4/20 | 0.39 |
| ▸ | TACR3 | P29371 | 4/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 7/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399916 | 0.99 | ALDH1A1 (0.42) | ALDH1A1TSHRRECQLL3MBTL1MBTD1 | |
| SCHEMBL13310392 | 0.99 | ALDH1A1 (0.42) | ALDH1A1TSHRRECQLL3MBTL1MBTD1 | |
| SCHEMBL3404354 | 0.92 | SIGMAR1 (0.46) | ALDH1A1ACHETACR2TACR3OPRM1 | |
| SCHEMBL3399827 | 0.92 | SIGMAR1 (0.43) | ALDH1A1HRH3ACHETACR2TACR3 | |
| SCHEMBL3399762 | 0.84 | KMT2A (0.45) | ALDH1A1 | |
| SCHEMBL3396799 | 0.84 | ACHE (0.40) | ALDH1A1ACHE | |
| SCHEMBL3404844 | 0.80 | ACHE (0.36) | TSHRACHE | |
| SCHEMBL3402347 | 0.79 | LMNA (0.36) | ALDH1A1ACHETACR2TACR3OPRM1 | |
| SCHEMBL3402431 | 0.79 | CCND1 (0.40) | ACHETACR2TACR3OPRM1 | |
| SCHEMBL3405131 | 0.79 | TLR8 (0.43) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |