Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404844 | 0.94 | ACHE (0.36) | ACHESLC6A4DRD2HTR7DRD4 | |
| SCHEMBL3396693 | 0.87 | HTR7 (0.40) | ACHESLC6A4DRD2HTR7SLC6A2 | |
| SCHEMBL3399762 | 0.85 | KMT2A (0.45) | LMNAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3396747 | 0.84 | ALDH1A1 (0.40) | ACHEALDH1A1 | |
| SCHEMBL3399916 | 0.83 | ALDH1A1 (0.42) | ACHEALDH1A1 | |
| SCHEMBL13310392 | 0.83 | ALDH1A1 (0.42) | ACHEALDH1A1 | |
| SCHEMBL3404354 | 0.82 | SIGMAR1 (0.46) | ACHEDRD4LMNAKDM4EALDH1A1 | |
| SCHEMBL3399827 | 0.82 | SIGMAR1 (0.43) | ACHEDRD4LMNAKDM4EALDH1A1 | |
| SCHEMBL3402431 | 0.80 | CCND1 (0.40) | ACHELMNAKDM4EMEN1KMT2A | |
| SCHEMBL3405131 | 0.80 | TLR8 (0.43) | SLC6A4DRD2SLC6A2SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |