Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.43 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29458043 | 1.00 | NPC1 (0.45) | NPC1RAB9AGRIN1GRIN2BSENP1 | |
| SCHEMBL3435915 | 1.00 | NPC1 (0.45) | NPC1RAB9AGRIN1GRIN2BSENP1 | |
| SCHEMBL3397185 | 1.00 | NPC1 (0.45) | NPC1RAB9AGRIN1GRIN2BSENP1 | |
| SCHEMBL3427572 | 0.97 | GRIN1 (0.45) | NPC1RAB9AGRIN1GRIN2BSENP1 | |
| SCHEMBL4339151 | 0.97 | GRIN1 (0.45) | NPC1RAB9AGRIN1GRIN2BSENP1 | |
| SCHEMBL3427709 | 0.92 | NPC1 (0.45) | NPC1RAB9AGRIN1GRIN2BSENP1 | |
| SCHEMBL3406007 | 0.92 | NPC1 (0.45) | NPC1RAB9AGRIN1GRIN2BSENP1 | |
| SCHEMBL3402815 | 0.88 | AMY1A (0.44) | NPC1RAB9AGRIN1GRIN2BSENP1 | |
| SCHEMBL4350999 | 0.88 | AMY1A (0.44) | NPC1RAB9AGRIN1GRIN2BSENP1 | |
| SCHEMBL3426908 | 0.88 | GRIN1 (0.32) | NPC1RAB9AGRIN1GRIN2BSENP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240197728-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING REFRACTORY EPILEPSY | INST NAT SANTE RECH MED (FR) | 2024-06-20 | — | — | US | disclosed |
| WO-2022219021-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING REFRACTORY EPILEPSY | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2022-10-20 | — | — | WO | disclosed |
| US-10702537-B2 | Devices and methods of treating methamphetamine addiction and medical and behavioral consequences of methamphetamine use and of HIV infection | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2020-07-07 | — | — | US | disclosed |
| US-10561668-B1 | Devices and methods of treating methamphetamine addiction and medical and behavioral consequences of methamphetamine use and of HIV infection | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY (US) | 2020-02-18 | — | — | US | disclosed |
| US-20190224211-A1 | DEVICES AND METHODS OF TREATING METHAMPHETAMINE ADDICTION AND MEDICAL AND BEHAVIORAL CONSEQUENCES OF METHAMPHETAMINE USE AND OF HIV INFECTION | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE | 2019-07-25 | — | — | US | disclosed |
| US-10022383-B2 | Devices and methods of treating methamphetamine addiction and medical and behavioral consequences of methamphetamine use and of HIV infection | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2018-07-17 | — | — | US | disclosed |
| WO-2017133517-A1 | PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF | 四川海思科制药有限公司 | 2017-08-10 | — | — | WO | disclosed |
| US-20160367565-A1 | DEVICES AND METHODS OF TREATING METHAMPHETAMINE ADDICTION AND MEDICAL AND BEHAVIORAL CONSEQUENCES OF METHAMPHETAMINE USE AND OF HIV INFECTION | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2016-12-22 | — | — | US | disclosed |
| EP-2250167-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | Chlorion Pharma, Inc. (CA) | 2010-11-17 | — | — | EP | disclosed |
| US-20090275538-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | UNIVERSITE LAVAL (CA) | 2009-11-05 | — | — | US | disclosed |
| US-20090275538-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | UNIVERSITE LAVAL (CA) | 2009-11-05 | — | — | US | disclosed |
| US-20090275538-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | UNIVERSITE LAVAL (CA) | 2009-11-05 | — | — | US | disclosed |
| WO-2009097695-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | CHLORION PHARMA, INC. (CA) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009097695-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | CHLORION PHARMA, INC. (CA) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275538-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | OPRL1, OPRK1, AHR | NPC1 2712/4885RAB9A 4212/4885GRIN1 944/4885 |
| US-10022383-B2 | Devices and methods of treating methamphetamine addiction and medical and behavioral consequences of methamphetamine use and of HIV infection | TSPO, SLC18A2, SLC18A3 | NPC1 551/4885RAB9A 1919/4885GRIN1 89/4885 |
| US-10561668-B1 | Devices and methods of treating methamphetamine addiction and medical and behavioral consequences of methamphetamine use and of HIV infection | TSPO, SLC18A2, SLC18A3 | NPC1 551/4885RAB9A 1919/4885GRIN1 89/4885 |
| US-20160367565-A1 | DEVICES AND METHODS OF TREATING METHAMPHETAMINE ADDICTION AND MEDICAL AND BEHAVIORAL CONSEQUENCES OF METHAMPHETAMINE USE AND OF HIV INFECTION | TSPO, SLC18A2, SLC18A3 | NPC1 551/4885RAB9A 1919/4885GRIN1 89/4885 |
| US-10702537-B2 | Devices and methods of treating methamphetamine addiction and medical and behavioral consequences of methamphetamine use and of HIV infection | TSPO, SLC18A2, SLC18A3 | NPC1 551/4885RAB9A 1919/4885GRIN1 89/4885 |
| US-20190224211-A1 | DEVICES AND METHODS OF TREATING METHAMPHETAMINE ADDICTION AND MEDICAL AND BEHAVIORAL CONSEQUENCES OF METHAMPHETAMINE USE AND OF HIV INFECTION | TSPO, SLC18A2, SLC18A3 | NPC1 551/4885RAB9A 1919/4885GRIN1 89/4885 |
| US-20240197728-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING REFRACTORY EPILEPSY | SLC6A13, SLC6A1, CLCN2 | NPC1 334/4885RAB9A 3241/4885GRIN1 554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.