Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.30 |
| ▸ | FNTB | P49356 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL445566 | 0.92 | TDP1 (0.31) | — | |
| SCHEMBL30808136 | 0.92 | TDP1 (0.31) | — | |
| SCHEMBL445565 | 0.92 | TDP1 (0.31) | — | |
| Methacrylic Acid SCHEMBL4418618 | 0.85 | TDP1 (0.38) | GRIK1 | |
| Sulfuric Acid SCHEMBL3395417 | 0.85 | — | — | |
| Lactic Acid SCHEMBL339900 | 0.84 | TP53 (0.38) | TP53GRIK1GRIK2 | |
| Acrylamide SCHEMBL21723571 | 0.83 | ALDH1A1 (0.41) | — | |
| Lactic Acid SCHEMBL339707 | 0.82 | TP53 (0.44) | TP53GRIK1GRIK2 | |
| Lactic Acid SCHEMBL339383 | 0.81 | TP53 (0.35) | TP53GRIK1GRIK2 | |
| Lactic Acid SCHEMBL339533 | 0.79 | TP53 (0.41) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10406079-B2 | Structures containing thermo-sensitive gels | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2019-09-10 | — | — | US | claimed |
| US-20180338891-A1 | STRUCTURES CONTAINING THERMO-SENSITIVE GELS | KIMBERLY CLARK CO (US) | 2018-11-29 | — | — | US | claimed |
| WO-2017095366-A1 | STRUCTURES CONTAINING THERMO-SENSITIVE GELS | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2017-06-08 | — | — | WO | claimed |
| US-10406079-B2 | Structures containing thermo-sensitive gels | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2019-09-10 | — | — | US | disclosed |
| US-20180338891-A1 | STRUCTURES CONTAINING THERMO-SENSITIVE GELS | KIMBERLY CLARK CO (US) | 2018-11-29 | — | — | US | disclosed |
| WO-2017095366-A1 | STRUCTURES CONTAINING THERMO-SENSITIVE GELS | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2017-06-08 | — | — | WO | disclosed |
| US-8110220-B2 | Temperature sensitive polymers | UNIVERSITEIT UTRECHT (NL) | 2012-02-07 | — | — | US | disclosed |
| US-20120015034-A1 | TEMPERATURE SENSITIVE POLYMERS | UNIVERSITEIT UTRECHT (NL) | 2012-01-19 | — | — | US | disclosed |
| EP-1776400-B1 | TEMPERATURE SENSITIVE POLYMERS | UNIVERSITEIT VAN UTRECHT (NL) | 2009-12-23 | — | — | EP | disclosed |
| WO-2009031105-A2 | NON-HOMOGENEOUS MODIFICATION OF LIQUIDS | KONINKLIJKE PHILIPS ELECTRONICS N. V. (NL) | 2009-03-12 | — | — | WO | disclosed |
| EP-2034028-A1 | Non-homogeneous modification of liquids | Koninklijke Philips Electronics N.V. (NL) | 2009-03-11 | — | — | EP | disclosed |
| US-7425581-B2 | Temperature sensitive polymers | UNIVERSITEIT UTRECHT | 2008-09-16 | — | — | US | disclosed |
| US-20080050435-A1 | Temperature Sensitive Polymers | CRISTAL DELIVERY B.V. (NL) | 2008-02-28 | — | — | US | disclosed |
| EP-1776400-A2 | TEMPERATURE SENSITIVE POLYMERS | Universiteit van Utrecht (NL) | 2007-04-25 | — | — | EP | disclosed |
| WO-2005087825-A2 | TEMPERATURE SENSITIVE POLYMERS | UNIVERSITEIT UTRECHT (NL) | 2005-09-22 | — | — | WO | disclosed |
| US-20040247670-A1 | Temperature sensitive polymers | CRISTAL DELIVERY B.V. (NL) | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080050435-A1 | Temperature Sensitive Polymers | LCT, LDHB, LDHA | TP53 1460/4885GRIK1 1650/4885GRIK2 1561/4885 |
| US-20120015034-A1 | TEMPERATURE SENSITIVE POLYMERS | LCT, LDHA, LDHB | TP53 1519/4885GRIK1 1286/4885GRIK2 1192/4885 |
| US-20040247670-A1 | Temperature sensitive polymers | LCT, LDHA, LDHB | TP53 2166/4885GRIK1 1719/4885GRIK2 1082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.