Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1GSK3AGSK3BHRH1HRH2HTR7IDH1IDH2IMPA1IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HMGCR | P04035 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 3/20 | 0.36 |
| ▸ | CPT2 | P23786 | 2/20 | 0.34 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL5190913 | 1.00 | CA4 (0.59) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL23320255 | 0.97 | CA4 (0.56) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL30165661 | 0.97 | CA4 (0.56) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL7517100 | 0.94 | CA4 (0.59) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL73102 | 0.94 | CA4 (0.67) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL7519382 | 0.94 | CA4 (0.59) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL1684058 | 0.94 | CA4 (0.59) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL10477647 | 0.94 | CA4 (0.67) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL2890971 | 0.94 | CA4 (0.67) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL183004 | 0.94 | CA4 (0.59) | CA4ALDH1A1HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 670 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12604898-B2 | Disilver hydrogen citrate-containing composition, method for producing same, antibacterial agent or antiviral agent using same, and method for producing same | SASAKI CHEMICAL INDUSTRY CO., LTD. (JP) | 2026-04-21 | — | — | US | claimed |
| EP-4169899-B1 | DISILVER HYDROGEN CITRATE-CONTAINING COMPOSITION, METHOD FOR PRODUCING SAME, ANTIBACTERIAL AGENT OR ANTIVIRAL AGENT USING SAME, AND METHOD FOR PRODUCING SAME | SASAKI CHEMICAL IND CO LTD (JP) | 2026-04-08 | — | — | EP | claimed |
| EP-4646581-A1 | PROCESS CONTROL OF SILVER-ION-BASED FOOD WASH PROCESSES | SmartWash Solutions, LLC. (US) | 2025-11-12 | — | — | EP | claimed |
| WO-2025226651-A1 | ENHANCED WASHING OF FOOD PRODUCTS | SMARTWASH SOLUTIONS, LLC (US) | 2025-10-30 | — | — | WO | claimed |
| US-20250324989-A1 | ENHANCED WASHING OF FOOD PRODUCTS | SMARTWASH SOLUTIONS LLC (US) | 2025-10-23 | — | — | US | claimed |
| US-20250324988-A1 | ENHANCED WASHING OF FOOD PRODUCTS | SMARTWASH SOLUTIONS LLC (US) | 2025-10-23 | — | — | US | claimed |
| EP-4604912-A1 | NATURAL SUBSTANCE-BASED HAIR DYEING METHOD | Henkel AG & Co. KGaA (DE) | 2025-08-27 | — | — | EP | claimed |
| CN-115569109-B | Gynecological antibacterial gel capable of being slowly released and preparation method thereof | 郑州伊品医药科技有限公司 | 2025-02-14 | — | — | CN | claimed |
| US-12137719-B2 | Short-term wash treatment of produce | SMARTWASH SOLUTIONS, LLC (US) | 2024-11-12 | — | — | US | claimed |
| WO-2024147925-A1 | PROCESS CONTROL OF SILVER-ION-BASED FOOD WASH PROCESSES | SMARTWASH SOLUTIONS, LLC (US) | 2024-07-11 | — | — | WO | claimed |
| EP-1675463-A2 | ANHYDROUS SILVER DIHYDROGEN CITRATE COMPOSITIONS | Pure Bioscience (US) | 2006-07-05 | — | — | EP | claimed |
| EP-1667601-A2 | SILVER DIHYDROGEN CITRATE COMPOSITIONS COMPRISING A SECOND ANTIMICROBIAL AGENT | Pure Bioscience (US) | 2006-06-14 | — | — | EP | claimed |
| US-20060115440-A1 | Silver dihydrogen citrate compositions | PURE BIOSCIENCE | 2006-06-01 | — | — | US | claimed |
| US-20060100273-A1 | Anhydrous silver dihydrogen citrate compositions | PURE BIOSCIENCE (US) | 2006-05-11 | — | — | US | claimed |
| WO-2006029213-A2 | SILVER DIHYDROGEN CITRATE COMPOSITIONS | PURE BIOSCIENCE (US) | 2006-03-16 | — | — | WO | claimed |
| US-20060051430-A1 | Silver dihydrogen citrate compositions | PURE BIOSCIENCE | 2006-03-09 | — | — | US | claimed |
| US-20050245605-A1 | Anhydrous silver dihydrogen citrate compositions | PURE BIOSCIENCE | 2005-11-03 | — | — | US | claimed |
| US-20050202066-A1 | Citric acid and a quaternary ammonium compound, an oxidizing agent of a halogen compound | PURE BIOSCIENCE | 2005-09-15 | — | — | US | claimed |
| WO-2005041861-A2 | ANHYDROUS SILVER DIHYDROGEN CITRATE COMPOSITIONS | PURE BIOSCIENCE (US) | 2005-05-12 | — | — | WO | claimed |
| WO-2005020915-A2 | SILVER DIHYDROGEN CITRATE COMPOSITIONS COMPRISING A SECOND ANTIMICROBIAL AGENT | PURE BIOSCIENCE (US) | 2005-03-10 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100273-A1 | Anhydrous silver dihydrogen citrate compositions | IDH1, IDH2, IDH3A | CA4 454/4885ALDH1A1 483/4885HMGCR 455/4885 |
| US-20060051430-A1 | Silver dihydrogen citrate compositions | IDH1, DSG1, SUCLG1 | CA4 1077/4885ALDH1A1 1006/4885HMGCR 770/4885 |
| US-20050245605-A1 | Anhydrous silver dihydrogen citrate compositions | IDH1, IDH2, IDH3A | CA4 454/4885ALDH1A1 483/4885HMGCR 455/4885 |
| US-20060115440-A1 | Silver dihydrogen citrate compositions | IDH1, DSG1, SUCLG1 | CA4 1077/4885ALDH1A1 1006/4885HMGCR 770/4885 |
| US-12604898-B2 | Disilver hydrogen citrate-containing composition, method for producing same, antibacterial agent or antiviral agent using same, and method for producing same | ACLY, CS, SAMHD1 | CA4 391/4885ALDH1A1 1979/4885HMGCR 925/4885 |
| US-20050202066-A1 | Citric acid and a quaternary ammonium compound, an oxidizing agent of a halogen compound | IDH1, IDH2, IDH3A | CA4 153/4885ALDH1A1 965/4885HMGCR 3155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.