Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401468 | 0.99 | PKM (0.49) | PKMRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL13310182 | 0.92 | LMNA (0.42) | PKMALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL13310362 | 0.85 | L3MBTL3 (0.45) | PKMLMNAKMT2AHTR2C | |
| SCHEMBL3398472 | 0.84 | PKM (0.44) | PKMRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL3398935 | 0.84 | HRH3 (0.39) | ALDH1A1LMNAKDM4EMAPTHTR2C | |
| SCHEMBL3403840 | 0.84 | HTR2C (0.47) | PKMRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL3403568 | 0.83 | RAB9A (0.45) | PKMRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL3404788 | 0.82 | HTR2C (0.39) | ALDH1A1LMNAKMT2ATSHRHTR2C | |
| SCHEMBL3405124 | 0.81 | NPC1 (0.45) | PKMRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL3404938 | 0.81 | HTR2C (0.48) | RAB9AALDH1A1HPGDSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |