Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.36 |
| ▸ | NQO2 | P16083 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 3/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | PRKACG | P22612 | 1/20 | 0.34 |
| ▸ | PRKACB | P22694 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400021 | 0.71 | PLA2G10 (0.42) | LMNAPLA2G10IKBKBPIM3PIM2 | |
| SCHEMBL11942291 | 0.70 | LMNA (0.47) | LMNANQO2DPP4DPP8GRM2 | |
| SCHEMBL7718641 | 0.68 | LMNA (0.54) | LMNANQO2GRM2PIM3PIM2 | |
| SCHEMBL26684911 | 0.65 | LMNA (0.55) | LMNANQO2DPP4DPP8GRM2 | |
| SCHEMBL31507558 | 0.65 | LMNA (0.55) | LMNANQO2DPP4DPP8GRM2 | |
| SCHEMBL9426333 | 0.64 | LMNA (0.48) | LMNANQO2KDM4EGRM2PIM3 | |
| SCHEMBL3112850 | 0.64 | LMNA (0.48) | LMNAIKBKBCHUKPRKACAPRKACG | |
| SCHEMBL16751985 | 0.63 | LMNA (0.44) | LMNADPP4DPP8RXFP1GRM2 | |
| SCHEMBL1292037 | 0.63 | MAPT (0.34) | LMNANOTUMKDM4EPRNPATM | |
| SCHEMBL6027026 | 0.62 | NOS2 (0.50) | LMNAGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247588-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009107850-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-03 | — | — | WO | disclosed |