Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3412354 | 0.83 | PTGS2 (0.39) | PLK1PTGS2IMPDH2ACP1TDO2 | |
| SCHEMBL3410261 | 0.83 | SYK (0.37) | TDO2ROCK2ROCK1DHODH | |
| SCHEMBL3413279 | 0.82 | CDK2 (0.46) | CDK9CCNT1CDK2JAK2 | |
| SCHEMBL3408556 | 0.79 | PLK1 (0.36) | PLK1PTGS2IMPDH2ACP1TDO2 | |
| SCHEMBL3407100 | 0.79 | MAPT (0.48) | PTGS2CDK2JAK2 | |
| SCHEMBL3411225 | 0.77 | MTTP (0.41) | IMPDH2 | |
| SCHEMBL3410530 | 0.77 | PLK1 (0.46) | PLK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3412730 | 0.77 | PIK3CA (0.40) | IMPDH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3409749 | 0.77 | IMPDH2 (0.42) | PLK1PTGS2IMPDH2PSEN1PSEN2 | |
| SCHEMBL3410226 | 0.76 | PLK1 (0.47) | PLK1CDK9CCNT1CDK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |