Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3411061 | 0.92 | SLC2A1 (0.48) | MAPTMAPK1HTTAURKAAURKB | |
| SCHEMBL3406844 | 0.91 | GALR2 (0.48) | MAPTMAPK1HTTAURKAAURKB | |
| SCHEMBL3406164 | 0.89 | IMPDH2 (0.45) | IMPDH2MAPTMAPK1TP53ZAP70 | |
| SCHEMBL3411892 | 0.88 | SLC2A1 (0.43) | MAPTMAPK1AURKAAURKBSLC2A1 | |
| SCHEMBL3409900 | 0.85 | AURKA (0.47) | JAK2AURKAAURKBSLC2A1BRD4 | |
| SCHEMBL3410260 | 0.84 | NPC1 (0.53) | IMPDH2MAPTMAPK1MEN1KMT2A | |
| SCHEMBL3410528 | 0.81 | GALR2 (0.42) | MAPTMAPK1ZAP70AURKAAURKB | |
| SCHEMBL3412580 | 0.81 | GALR2 (0.44) | MAPTZAP70AURKAAURKBSLC2A1 | |
| SCHEMBL3406068 | 0.80 | NPC1 (0.46) | IMPDH2MAPTTSHRHTTMEN1 | |
| SCHEMBL3407955 | 0.79 | NPC1 (0.51) | IMPDH2MAPTMEN1KMT2ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |