Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | GALR2 | O43603 | 2/20 | 0.38 |
| ▸ | GALR1 | P47211 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3411061 | 0.89 | SLC2A1 (0.48) | AURKAAURKBSLC2A1BRD4GALR2 | |
| SCHEMBL3406844 | 0.88 | GALR2 (0.48) | AURKAAURKBSLC2A1BRD4GALR2 | |
| SCHEMBL3413403 | 0.85 | IMPDH2 (0.49) | AURKAAURKBSLC2A1BRD4JAK2 | |
| SCHEMBL3411892 | 0.85 | SLC2A1 (0.43) | AURKAAURKBSLC2A1BRD4PDE7A | |
| SCHEMBL3410260 | 0.81 | NPC1 (0.53) | BRD4 | |
| SCHEMBL4090603 | 0.79 | PSEN1 (0.51) | AURKA | |
| SCHEMBL3410528 | 0.79 | GALR2 (0.42) | AURKAAURKBSLC2A1GALR2GALR1 | |
| SCHEMBL3412580 | 0.78 | GALR2 (0.44) | AURKAAURKBSLC2A1GALR2GALR1 | |
| SCHEMBL3406068 | 0.77 | NPC1 (0.46) | BRD4 | |
| SCHEMBL3407955 | 0.76 | NPC1 (0.51) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |