Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL977202 | 0.92 | CCR2 (0.39) | CCR2CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL3654201 | 0.91 | F2 (0.39) | CCR2DRD2DRD3POLBF2 | |
| SCHEMBL977615 | 0.91 | ALOX5 (0.39) | CCR2DRD2DRD3POLBF2 | |
| SCHEMBL3408675 | 0.90 | DRD2 (0.40) | DRD2DRD3POLBF2L3MBTL1 | |
| SCHEMBL3659526 | 0.89 | F2 (0.46) | CCR2DRD2DRD3POLBF2 | |
| Hydrochloric Acid SCHEMBL6519318 | 0.89 | DRD2 (0.39) | DRD2DRD3F2L3MBTL1ALOX5 | |
| SCHEMBL3662481 | 0.89 | F2 (0.37) | CCR2DRD2DRD3POLBF2 | |
| SCHEMBL3406225 | 0.88 | SCN9A (0.41) | DRD2DRD3L3MBTL1ALOX5EPHX2 | |
| SCHEMBL3660828 | 0.87 | RHOC (0.47) | CCR2F2 | |
| SCHEMBL3658255 | 0.86 | F2 (0.36) | CCR2DRD2DRD3F2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234966-A2 | AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | Sanofi-Aventis (FR) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009106708-A2 | AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI-AVENTIS (FR) | 2009-09-03 | — | — | WO | disclosed |