Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.66 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | HTT | P42858 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7534183 | 0.90 | HTR6 (0.56) | HTR6FFAR4LMNAMEN1KMT2A | |
| SCHEMBL5622505 | 0.87 | CYP19A1 (0.64) | FFAR4LMNAMEN1KMT2AHTT | |
| SCHEMBL399122 | 0.86 | LMNA (0.77) | HTR6LMNAMEN1KMT2AHTT | |
| SCHEMBL5281087 | 0.86 | LMNA (0.61) | HTR6LMNAMEN1KMT2AHTT | |
| SCHEMBL6678901 | 0.85 | LMNA (0.60) | HTR6LMNAMEN1KMT2AHTT | |
| SCHEMBL22095988 | 0.85 | CA12 (0.76) | LMNAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL7538266 | 0.84 | ALDH1A1 (0.59) | HTR6FFAR4LMNAMEN1KMT2A | |
| SCHEMBL9045758 | 0.82 | LMNA (0.63) | HTR6LMNAMEN1KMT2AHTT | |
| SCHEMBL7171823 | 0.82 | HTR6 (0.62) | HTR6LMNAMEN1KMT2AHTT | |
| SCHEMBL8648029 | 0.82 | PTGS2 (0.59) | HTR6LMNAKMT2AHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022127914-A1 | NUCLEOSIDE-THIODIPHOSPHATE-HEPTOSE COMPOUNDS FOR TREATING CONDITIONS ASSOCIATED WITH ALPK1 ACTIVITY | PYROTECH (BEIJING) BIOTECHNOLOGY CO., LTD. (CN) | 2022-06-23 | — | — | WO | disclosed |
| WO-2019148410-A1 | ANTI-PD-1 ANTIBODIES | MERCK SHARP & DOHME CORP. (US) | 2019-08-08 | — | — | WO | disclosed |
| CN-103946223-B | 3-cyanaryl-1h-pyrazolo[2.3-b]pyridine derivatives | 默克专利股份公司 | 2017-01-18 | — | — | CN | disclosed |
| CN-103459420-B | For treating compositions and the method for tumor | 泽斯塔根股份有限公司 | 2016-09-28 | — | — | CN | disclosed |
| CN-104093722-B | Furo [3,2-b]-and thieno [3,2-b] pyridine derivate as TBK1 and IKK inhibitor | 默克专利股份公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105732617-A | 7-azaindole derivatives | 默克专利股份公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-105712991-A | 7-AZAINDOLE DERIVATIVES | 默克专利股份公司 | 2016-06-29 | — | — | CN | disclosed |
| WO-2016095088-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016095089-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |
| WO-2015051766-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY (ADP-RIBOSE) POLYMERASE INHIBITORS | BETTA PHARMACEUTICALS CO., LTD (CN) | 2015-04-16 | — | — | WO | disclosed |
| EP-1747214-A2 | DIHYDROBENZOTHIOPHENES | MERCK PATENT GmbH (DE) | 2007-01-31 | — | — | EP | disclosed |
| WO-2006133805-A1 | TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2006-12-21 | — | — | WO | disclosed |
| EP-1727820-A2 | AMINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-12-06 | — | — | EP | disclosed |
| EP-1720846-A1 | USE OF THIADIAZOLE UREA DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-11-15 | — | — | EP | disclosed |
| WO-2006105844-A1 | PYRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2006-10-12 | — | — | WO | disclosed |
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005108355-A2 | DIHYDROBENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2005-11-17 | — | — | WO | disclosed |
| WO-2005085220-A1 | USE OF THIADIAZOLE UREA DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-09-15 | — | — | WO | disclosed |
| WO-2005054246-A2 | AMINE DERIVATIVES HAVING A TYROSINE-KINASE-INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2005-06-16 | — | — | WO | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |