Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 4-Nitroaniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Nitroaniline SCHEMBL6600220 | 0.95 | ALDH1A1 (0.42) | SLC6A3ALDH1A1SLC1A3SLC1A2SLC1A1 | |
| 4-Nitroaniline SCHEMBL16269538 | 0.93 | SLC6A3 (0.40) | SLC6A3ALDH1A1SLC1A3SLC1A2SLC1A1 | |
| 4-Nitroaniline SCHEMBL3413641 | 0.87 | ALDH1A1 (0.50) | SLC6A3ALDH1A1ESR1CYP19A1ESR2 | |
| Phenylalanine SCHEMBL3431329 | 0.84 | DPP4 (0.41) | SLC6A3KMT2APKMMEN1MAPT | |
| Phenylalanine SCHEMBL8981660 | 0.84 | DPP4 (0.41) | SLC6A3KMT2APKMMEN1MAPT | |
| Valine SCHEMBL2113294 | 0.82 | SLC7A5 (0.47) | ALDH1A1KMT2AMEN1DPP4DPP8 | |
| Valine SCHEMBL8740685 | 0.82 | SLC7A5 (0.47) | ALDH1A1KMT2AMEN1DPP4DPP8 | |
| Valine SCHEMBL28486680 | 0.82 | SLC7A5 (0.47) | ALDH1A1KMT2AMEN1DPP4DPP8 | |
| 4-Nitroaniline SCHEMBL5768376 | 0.81 | ALDH1A1 (0.44) | SLC6A3ALDH1A1ESR1CYP19A1ESR2 | |
| 4-Nitroaniline SCHEMBL29058965 | 0.80 | ALDH1A1 (0.58) | ALDH1A1SLC1A3SLC1A2SLC1A1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1269990-B1 | Cosmetic or dermatological composition comprising acylaminoamide derivatives | OREAL (FR) | 2010-10-13 | — | — | EP | disclosed |
| EP-1269988-B1 | Cosmetic or dermatological composition comprising acylaminoamide derivatives | OREAL (FR) | 2007-12-05 | — | — | EP | disclosed |
| EP-1275372-B1 | Cosmetic or dermatological composition comprising a N-acylaminoamide derivative and a metalloproteinase inhibitor | OREAL (FR) | 2007-06-13 | — | — | EP | disclosed |
| EP-1399113-B1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING N-ACYLAMINOAMIDE DERIVATIVES | OREAL (FR) | 2007-03-21 | — | — | EP | disclosed |
| EP-1292608-B1 | NOVEL COMPOUNDS OF THE N-ACYLAMINO-AMIDE FAMILY, COMPOSITIONS COMPRISING SAME, AND USES | OREAL (FR) | 2004-07-21 | — | — | EP | disclosed |
| EP-1292608-A2 | NOVEL COMPOUNDS OF THE N-ACYLAMINO-AMIDE FAMILY, COMPOSITIONS COMPRISING SAME, AND USES | L'OREAL (FR) | 2003-03-19 | — | — | EP | disclosed |
| US-20030044438-A1 | Cosmetic or dermatological composition comprising an association between a compound of the N-acylaminoamide family and at least one matrix metalloproteinase inhibitor | L'OREAL (FR) | 2003-03-06 | — | — | US | disclosed |
| EP-1275372-A1 | Cosmetic or dermatological composition comprising a N-acylaminoamide derivative and a metalloproteinase inhibitor | L'OREAL, S.A. (FR) | 2003-01-15 | — | — | EP | disclosed |
| EP-1269989-A1 | Cosmetic or dermatological composition comprising acylaminoamide derivatives | L'OREAL (FR) | 2003-01-02 | — | — | EP | disclosed |
| EP-1269988-A1 | Cosmetic or dermatological composition comprising acylaminoamide derivatives | L'OREAL (FR) | 2003-01-02 | — | — | EP | disclosed |
| EP-1269990-A1 | Cosmetic or dermatological composition comprising acylaminoamide derivatives | L'OREAL (FR) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001094381-A2 | NOVEL COMPOUNDS OF THE N-ACYLAMINO-AMIDE FAMILY, COMPOSITIONS COMPRISING SAME, AND USES | L'OREAL (FR) | 2001-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030044438-A1 | Cosmetic or dermatological composition comprising an association between a compound of the N-acylaminoamide family and at least one matrix metalloproteinase inhibitor | SERPINB1, ELANE, MMP7 | SLC6A3 4728/4885ALDH1A1 573/4885SLC1A3 4141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.