Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3413674 | 1.00 | ALDH1A1 (0.49) | ALDH1A1BCHEHDAC6MEN1KMT2A | |
| SCHEMBL3410772 | 0.88 | MAOB (0.44) | ALDH1A1HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL3407865 | 0.88 | MAOB (0.44) | ALDH1A1HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL3413189 | 0.86 | MAPT (0.47) | ALDH1A1HDAC6MEN1KMT2ATDP1 | |
| SCHEMBL3408917 | 0.81 | AR (0.39) | ALDH1A1 | |
| SCHEMBL6285224 | 0.68 | ALDH1A1 (0.47) | ALDH1A1BCHEHDAC6MEN1KMT2A | |
| SCHEMBL3387075 | 0.67 | ALDH1A1 (0.60) | ALDH1A1HDAC6MEN1KMT2APOLB | |
| SCHEMBL17622984 | 0.67 | KMT2A (0.73) | ALDH1A1HDAC6MEN1KMT2APOLB | |
| SCHEMBL571502 | 0.66 | ALDH1A1 (0.64) | ALDH1A1HDAC6MEN1KMT2APOLB | |
| SCHEMBL12601424 | 0.64 | ALDH1A1 (0.62) | ALDH1A1HDAC6MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063118-A1 | Hydantoins Having RNase Modulatory Activity | WYETH (US) | 2010-03-11 | — | — | US | claimed |
| WO-2005090316-A1 | HYDANTOINS HAVING RNase MODULATORY ACTIVITY | WYETH (US) | 2005-09-29 | — | — | WO | claimed |
| US-20050203156-A1 | Hydantoins having RNase modulatory activity | WYETH (US) | 2005-09-15 | — | — | US | claimed |
| US-20100063118-A1 | Hydantoins Having RNase Modulatory Activity | WYETH (US) | 2010-03-11 | — | — | US | disclosed |
| WO-2005090316-A1 | HYDANTOINS HAVING RNase MODULATORY ACTIVITY | WYETH (US) | 2005-09-29 | — | — | WO | disclosed |
| US-20050203156-A1 | Hydantoins having RNase modulatory activity | WYETH (US) | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063118-A1 | Hydantoins Having RNase Modulatory Activity | RNASEH1, RNASE1, RNASEL | ALDH1A1 1439/4885BCHE 825/4885HDAC6 572/4885 |
| US-20050203156-A1 | Hydantoins having RNase modulatory activity | RNASEH1, RNASE1, RNASEL | ALDH1A1 1439/4885BCHE 825/4885HDAC6 572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.