Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 8/20 | 0.51 |
| ▸ | CTSL | P07711 | 7/20 | 0.51 |
| ▸ | CTSS | P25774 | 7/20 | 0.51 |
| ▸ | CTSB | P07858 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | KYNU | Q16719 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2342652 | 1.00 | CTSK (0.51) | CTSKCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL4313267 | 0.88 | FOLH1 (0.52) | CTSKCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL4313271 | 0.88 | FOLH1 (0.52) | CTSKCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL2345022 | 0.87 | SYK (0.51) | CTSKCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL2345024 | 0.87 | SYK (0.51) | CTSKCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL15101058 | 0.85 | CTSL (0.50) | CTSKCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL22982779 | 0.84 | CYP3A4 (0.49) | CTSKCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL7274758 | 0.84 | CYP3A4 (0.49) | CTSKCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL7417082 | 0.84 | CTSK (0.51) | CTSKCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL3012475 | 0.83 | CASP1 (0.56) | CTSKCTSLCTSSCTSBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257533-A1 | 3-SUBSTITUTED-1,4-DIAZEPAN-2-ONE MELANOCORTIN-5 RECEPTOR ANTAGONISTS | Mimetica Pty Limited (AU) | 2010-12-08 | — | — | EP | disclosed |
| EP-2257297-A1 | METHODS OF MODULATING THE ACTIVITY OF THE MC5 RECEPTOR AND TREATMENT OF CONDITIONS RELATED TO THIS RECEPTOR | Mimetica Pty Limited (AU) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009105824-A1 | METHODS OF MODULATING THE ACTIVITY OF THE MC5 RECEPTOR AND TREATMENT OF CONDITIONS RELATED TO THIS RECEPTOR | MIMETICA PTY LTD (AU) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009105825-A1 | 3-SUBSTITUTED-1,4-DIAZEPAN-2-ONE MELANOCORTIN-5 RECEPTOR ANTAGONISTS | MIMETICA PTY LTD (AU) | 2009-09-03 | — | — | WO | disclosed |