Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Benzil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 14/20 | 0.61 |
| ▸ | CES1 | P23141 | 13/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzil SCHEMBL4351569 | 0.98 | CES2 (0.64) | CES2CES1RAB9AALDH1A1KDM4E | |
| Benzil SCHEMBL5027688 | 0.96 | CES2 (0.61) | CES2CES1RAB9AALDH1A1KDM4E | |
| Benzoyl Formic Acid SCHEMBL5494525 | 0.89 | CES2 (0.55) | CES2CES1RAB9AALDH1A1KDM4E | |
| Benzophenone SCHEMBL8962994 | 0.84 | ALDH1A1 (0.66) | RAB9AALDH1A1KDM4EMAPTAGTR1 | |
| Benzoic Acid SCHEMBL1463186 | 0.84 | TSHR (0.64) | CES2CES1ALDH1A1KDM4EMAPT | |
| Benzil SCHEMBL7112388 | 0.84 | CES2 (0.78) | CES2CES1RAB9AALDH1A1KDM4E | |
| Benzil SCHEMBL4356607 | 0.83 | CES2 (0.61) | CES2CES1RAB9AALDH1A1HPGD | |
| SCHEMBL27692626 | 0.83 | ALDH1A1 (0.50) | CES2CES1ALDH1A1KDM4EMAPT | |
| Benzil SCHEMBL3416500 | 0.81 | CES2 (0.74) | CES2CES1RAB9AMAPTNPSR1 | |
| Benzil SCHEMBL337491 | 0.81 | CES2 (0.74) | CES2CES1RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838304-B2 | Liquid reagent of color former and method of stabilizing the same | ARKRAY, INC. (JP) | 2010-11-23 | — | — | US | disclosed |
| US-20090053823-A1 | Liquid Reagent of Color Former and Method of Stabilizing The Same | ARKRAY, INC. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1985670-A1 | LIQUID REAGENT OF COLOR FORMER AND METHOD OF STABILIZING THE SAME | Arkray, Inc. (JP) | 2008-10-29 | — | — | EP | disclosed |