Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 10/20 | 0.55 |
| ▸ | CES1 | P23141 | 10/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzil SCHEMBL4351569 | 0.91 | CES2 (0.64) | CES2CES1ALDH1A1KDM4EMAPT | |
| Benzil SCHEMBL3415965 | 0.89 | CES2 (0.61) | CES2CES1ALDH1A1KDM4EMAPT | |
| Benzil SCHEMBL5027688 | 0.89 | CES2 (0.61) | CES2CES1ALDH1A1KDM4EMAPT | |
| Benzophenone SCHEMBL8962994 | 0.83 | ALDH1A1 (0.66) | ALDH1A1KDM4EMAPTAGTR1NPSR1 | |
| Benzoic Acid SCHEMBL1463186 | 0.83 | TSHR (0.64) | CES2CES1ALDH1A1KDM4EMAPT | |
| Benzoyl Formic Acid SCHEMBL15180795 | 0.82 | CES2 (0.77) | CES2CES1ALDH1A1KDM4EMAPT | |
| Benzoyl Formic Acid SCHEMBL38943 | 0.82 | CES2 (0.77) | CES2CES1ALDH1A1KDM4EMAPT | |
| Benzoyl Formic Acid SCHEMBL15180811 | 0.82 | CES2 (0.77) | CES2CES1ALDH1A1KDM4EMAPT | |
| Benzoyl Formic Acid SCHEMBL15180809 | 0.82 | CES2 (0.77) | CES2CES1ALDH1A1KDM4EMAPT | |
| Benzoyl Formic Acid SCHEMBL15180800 | 0.82 | CES2 (0.77) | CES2CES1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100358909-C | Bidentate C, P chiral phosphine ligands | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | CN | disclosed |
| EP-1567535-B1 | BIDENTATE C,P CHIRAL PHOSPHINE LIGANDS | HOFFMANN LA ROCHE (CH) | 2007-01-17 | — | — | EP | disclosed |
| US-6984744-B2 | Phosphine ligands | HOFFMAN-LA ROCHE INC. (US) | 2006-01-10 | — | — | US | disclosed |
| CN-1717410-A | Bidentate C, P chiral phosphine ligand | HOFFMANN LA ROCHE (CH) | 2006-01-04 | — | — | CN | disclosed |
| EP-1567535-A1 | BIDENTATE C,P CHIRAL PHOSPHINE LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050669-A1 | BIDENTATE C,P CHIRAL PHOSPHINE LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-17 | — | — | WO | disclosed |
| US-20040110975-A1 | 2-(2-phosphinoethyl)phospholanes and transition metal complexes with such ligands in asymmetric hydrogenation reactions; phospholone intermediates | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110975-A1 | 2-(2-phosphinoethyl)phospholanes and transition metal complexes with such ligands in asymmetric hydrogenation reactions; phospholone intermediates | CCRL2, LUC7L2, CDKL1 | CES2 987/4885CES1 2020/4885ALDH1A1 4475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.