SCHEMBL3416154

SCHEMBL3416154

CN(C)CCNc1cccc2c1C(=O)c1c(NCCN(C)C)cccc1C2=O

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TERT O14746 6/20 0.62
MAPT P10636 4/20 0.55
SMN1; SMN2 Q16637 3/20 0.55
MEN1 O00255 3/20 0.55
KMT2A Q03164 3/20 0.55
EGFR P00533 2/20 0.55
MAPK1 P28482 2/20 0.55
L3MBTL1 Q9Y468 2/20 0.55
ALDH1A1 P00352 2/20 0.55
POLB P06746 2/20 0.55
RAD52 P43351 2/20 0.55
LMNA P02545 1/20 0.55
HTT P42858 1/20 0.55
RECQL P46063 1/20 0.55
BLM P54132 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
MALT1 Q9UDY8 1/20 0.53
NSD2 O96028 1/20 0.49
FGB P02675 1/20 0.49
MMP14 P50281 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3418821 0.95 TERT (0.61) TERTMAPTSMN1; SMN2MEN1KMT2A
SCHEMBL31218585 0.94 MAPT (0.63) TERTMAPTSMN1; SMN2MEN1KMT2A
SCHEMBL3418752 0.94 MAPT (0.63) TERTMAPTSMN1; SMN2MEN1KMT2A
SCHEMBL3853558 0.91 TERT (0.63) TERTMAPTSMN1; SMN2MEN1KMT2A
SCHEMBL13434540 0.91 TERT (0.57) TERTMAPTSMN1; SMN2MEN1KMT2A
SCHEMBL14882640 0.89 TERT (0.56) TERTMAPTSMN1; SMN2MEN1KMT2A
SCHEMBL29852887 0.89 TERT (0.56) TERTMAPTSMN1; SMN2MEN1KMT2A
SCHEMBL5086164 0.89 TERT (0.56) TERTMAPTSMN1; SMN2MEN1KMT2A
SCHEMBL3415549 0.88 NSD2 (0.62) TERTMAPTSMN1; SMN2MEN1KMT2A
SCHEMBL12283017 0.88 TERT (0.55) TERTMAPTSMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9334281-B2 Fluorochromes for organelle tracing and multi-color imaging ENZO LIFE SCIENCES, INC. (US) 2016-05-10 US disclosed
US-9334281-B2 Fluorochromes for organelle tracing and multi-color imaging ENZO LIFE SCIENCES, INC. (US) 2016-05-10 US disclosed
US-9334281-B2 Fluorochromes for organelle tracing and multi-color imaging ENZO LIFE SCIENCES, INC. (US) 2016-05-10 US disclosed
US-8715944-B2 Fluorochromes for organelle tracing and multi-color imaging ENZO LIFE SCIENCES, INC. (US) 2014-05-06 US disclosed
US-8715944-B2 Fluorochromes for organelle tracing and multi-color imaging ENZO LIFE SCIENCES, INC. (US) 2014-05-06 US disclosed
US-8715944-B2 Fluorochromes for organelle tracing and multi-color imaging ENZO LIFE SCIENCES, INC. (US) 2014-05-06 US disclosed
US-20100062429-A1 Fluorochromes for organelle tracing and multi-color imaging ENZO LIFE SCIENCES, INC. 2010-03-11 US disclosed
US-20100062429-A1 Fluorochromes for organelle tracing and multi-color imaging ENZO LIFE SCIENCES, INC. 2010-03-11 US disclosed
US-20100062429-A1 Fluorochromes for organelle tracing and multi-color imaging ENZO LIFE SCIENCES, INC. 2010-03-11 US disclosed
WO-2010028349-A2 FLUOROCHROMES FOR ORGANELLE TRACING AND MULTI-COLOR IMAGING ENZO LIFE SCIENCES, INC. (US) 2010-03-11 WO disclosed
US-20100062460-A1 Novel fluorochromes for organelle tracing and multi-color imaging ENZO LIFE SCIENCES, INC. 2010-03-11 US disclosed
US-20100062460-A1 Novel fluorochromes for organelle tracing and multi-color imaging ENZO LIFE SCIENCES, INC. 2010-03-11 US disclosed
US-20100062460-A1 Novel fluorochromes for organelle tracing and multi-color imaging ENZO LIFE SCIENCES, INC. 2010-03-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100062429-A1 Fluorochromes for organelle tracing and multi-color imaging MFN2, TFEB, NDC1 TERT 2256/4885MAPT 469/4885SMN1; SMN2 2076/4885
US-20100062460-A1 Novel fluorochromes for organelle tracing and multi-color imaging MFN2, TFEB, NUMA1 TERT 2763/4885MAPT 574/4885SMN1; SMN2 2265/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.