Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 11/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 11/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 11/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 11/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 11/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 11/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3388523 | 0.81 | BRD4 (0.49) | TGFBR1RXRARXRBRXRG | |
| SCHEMBL30353435 | 0.79 | RXRA (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27480602 | 0.79 | RXRA (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3433756 | 0.77 | TGFBR1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2183673 | 0.75 | CTSK (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2183876 | 0.74 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4260357 | 0.74 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27705669 | 0.74 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3390266 | 0.74 | ACACA (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3418697 | 0.74 | TGFBR1 (0.42) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052448-A2 | FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-05-14 | — | — | WO | disclosed |