Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Benzylimidazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzylimidazole SCHEMBL1123480 | 0.91 | ALDH1A1 (0.49) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Benzylimidazole SCHEMBL339106 | 0.89 | ALDH1A1 (0.46) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Benzylimidazole SCHEMBL16237306 | 0.88 | CHKA (0.46) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Benzylimidazole SCHEMBL3786784 | 0.88 | ALDH1A1 (0.44) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Benzylimidazole SCHEMBL16236716 | 0.84 | ALDH1A1 (0.41) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Benzylimidazole SCHEMBL16237353 | 0.82 | ALDH1A1 (0.41) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Benzylimidazole SCHEMBL7942344 | 0.82 | ALDH1A1 (0.41) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Benzylimidazole SCHEMBL28855087 | 0.81 | NPSR1 (0.40) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Benzylimidazole SCHEMBL16237033 | 0.80 | FDPS (0.43) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Benzylimidazole SCHEMBL16699274 | 0.80 | ALDH1A1 (0.47) | ALDH1A1KDM4ERAB9ACHKALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010033014-A2 | METHOD FOR PREPARATION OF REGENERATIVE IMIDAZOLIUM REAGENTS | MIMOS BERHAD (MY) | 2010-03-25 | — | — | WO | disclosed |