SCHEMBL341906

SCHEMBL341906

COc1ccc(C)cc1C(=O)NS(=O)(=O)c1ccc(C(=O)NC2CC2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.55
KMT2A Q03164 3/20 0.52
MEN1 O00255 2/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
LMNA P02545 4/20 0.49
MAPT P10636 3/20 0.49
CYP1A2 P05177 2/20 0.49
CYP2C19 P33261 2/20 0.49
ABCC3 O15438 1/20 0.49
ABCC4 O15439 1/20 0.49
ABCC9 O60706 1/20 0.49
ABCB11 O95342 1/20 0.49
ALDH1A1 P00352 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
CFTR P13569 1/20 0.49
TSHR P16473 1/20 0.49
HTR2A P28223 1/20 0.49
PPARG P37231 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12831717 0.89 NLRP3 (0.61) KMT2AMEN1LMNAMAPTCYP1A2
SCHEMBL29687002 0.86 KCNA3 (0.52) HPGDKMT2AMEN1LMNAFLT1
SCHEMBL120129 0.86 KCNA3 (0.52) HPGDKMT2AMEN1LMNAFLT1
SCHEMBL3655826 0.86 KCNA3 (0.52) HPGDKMT2AMEN1LMNAFLT1
SCHEMBL4336890 0.85 THRB (0.47) HPGDKMT2AMEN1LMNAALDH1A1
SCHEMBL6051166 0.82 KDM4E (0.50) KMT2ALMNAMAPTALDH1A1CYP2D6
SCHEMBL14391696 0.79 NPC1 (0.56) HPGDKMT2AL3MBTL1MAPTALDH1A1
SCHEMBL626675 0.78 KMT2A (0.48) KMT2AMEN1LMNAMAPTALDH1A1
SCHEMBL15087952 0.77 LMNA (0.62) HPGDKMT2AMEN1L3MBTL1LMNA
SCHEMBL2615504 0.76 PPARG (0.84) KMT2AMEN1L3MBTL1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 550 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11202447-B2 Herbicides based on substituted thien-3-yl-sulphonylamino(thio)carbonyl-triazolin(thi)ones and 4-HPPD-inhibitors BAYER INTELLECTUAL PROPERTY GMBH (DE) 2021-12-21 US claimed
EP-2099751-B1 BIPHENYL-SUBSTITUTED SPIROCYCLIC KETOENOLS BAYER IP GMBH (DE) 2018-05-30 EP claimed
EP-2842426-B1 Herbicide based on a substituted thien-3-yl-sulfonylamino(thio)carbonyl-triazolin(thi)one and a 4-HPPD inhibitor BAYER CROPSCIENCE AG (DE) 2017-09-27 EP claimed
US-20160000076-A1 Fungicidal Active Compound Combinations BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-01-07 US claimed
EP-2185563-B1 OXASPIROCYCLIC SPIRO-SUBSTITUTED TETRAMIC AND TETRONIC ACID DERIVATIVES BAYER IP GMBH (DE) 2015-08-19 EP claimed
EP-1943218-B1 ALKOXYALKYL SPIROCYCLIC TETRAMIC ACIDS AND TETRONIC ACIDS BAYER IP GMBH (DE) 2015-05-06 EP claimed
US-8993782-B2 Cis-alkoxyspirocyclic biphenyl-substituted tetramic acid derivatives BAYER CROPSCIENCE AG (DE) 2015-03-31 US claimed
EP-2195290-B1 HALOGEN ALKOXY SPIROCYCLIC TETRAMIC AND TETRONIC ACID DERIVATIVES BAYER IP GMBH (DE) 2015-03-11 EP claimed
EP-2842426-A1 New herbicide based on substituted thien-3-yl-sulfonylamino(thio)carbonyl-triazolin(thi)ones and 4-HPPD inhibitors Bayer CropScience AG (DE) 2015-03-04 EP claimed
EP-2836072-A1 HERBICIDAL COMPOSITION COMPRISING URACIL COMPOUND AS ACTIVE INGREDIENT Dongbu Farm Hannong Co., Ltd. (KR) 2015-02-18 EP claimed
EP-1303189-A1 ARYL SULFONYL AMINO CARBONYL TRIAZOLE BASED SELECTIVE HERBICIDES Bayer CropScience AG (DE) 2003-04-23 EP claimed
WO-2003026426-A1 HERBICIDES CONTAINING SUBSTITUTED THIEN-3-YL-SULFONYLAMINO(THIO)CARBONYL-TRIAZOLIN(THI)ONE BAYER CROPSCIENCE AG (DE) 2003-04-03 WO claimed
CN-1407854-A N-aryi-uracile-based herbicides BAYER AG (DE) 2003-04-02 CN claimed
WO-2003017766-A2 HERBICIDES MADE FROM SUBSTITUTED ARYL KETONES BAYER CROPSCIENCE AG (DE) 2003-03-06 WO claimed
WO-2003013249-A1 SELECTIVE HERBICIDES BASED ON SUBSTITUTED CYCLIC KETO-ENOLS AND SAFENERS BAYER CROPSCIENCE AG (DE) 2003-02-20 WO claimed
EP-1278413-A2 N-ARYL-URACILE-BASED HERBICIDES Bayer CropScience AG (DE) 2003-01-29 EP claimed
WO-2002071845-A1 HERBICIDES BASED ON SUBSTITUTED ARYL KETONES BAYER CROPSCIENCE AG (DE) 2002-09-19 WO claimed
WO-2002063957-A2 SELECTIVE SUBSTITUTED ARYL KETONE AND SAFENER BASED HERBICIDES BAYER CROPSCIENCE AG (DE) 2002-08-22 WO claimed
WO-2002001957-A1 ARYL SULFONYL AMINO CARBONYL TRIAZOLE BASED SELECTIVE HERBICIDES BAYER CROPSCIENCE AG (DE) 2002-01-10 WO claimed
WO-2001039597-A2 N-ARYL-URACILE-BASED HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 2001-06-07 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11202447-B2 Herbicides based on substituted thien-3-yl-sulphonylamino(thio)carbonyl-triazolin(thi)ones and 4-HPPD-inhibitors HPD, DDT, TH HPGD 133/4885KMT2A 437/4885MEN1 4823/4885
US-20160000076-A1 Fungicidal Active Compound Combinations DDT, CYP4X1, CYP51A1 HPGD 2294/4885KMT2A 1264/4885MEN1 3706/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.