Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13246764 | 0.77 | LMNA (0.30) | LMNACYP2C9 | |
| SCHEMBL26044406 | 0.68 | LMNA (0.39) | LMNACYP2C9 | |
| SCHEMBL25462618 | 0.67 | LMNA (0.34) | LMNACYP2C9 | |
| SCHEMBL19250232 | 0.63 | SLC6A4 (0.32) | — | |
| SCHEMBL8079753 | 0.62 | LMNA (0.42) | LMNACYP2C9 | |
| SCHEMBL14298073 | 0.62 | LMNA (0.42) | LMNACYP2C9 | |
| SCHEMBL4667124 | 0.61 | CYP2C9 (0.48) | LMNACYP2C9 | |
| SCHEMBL19254913 | 0.61 | LMNA (0.37) | LMNACYP2C9 | |
| SCHEMBL25460577 | 0.61 | ALDH1A1 (0.35) | LMNACYP2C9 | |
| SCHEMBL21216586 | 0.60 | LMNA (0.40) | LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859641-B1 | DOPAMINE TRANSPORTER IMAGING AGENT | HARVARD COLLEGE (US) | 2012-10-17 | — | — | EP | disclosed |
| EP-1051980-B1 | Dopamine transporter imaging agents | HARVARD COLLEGE (US) | 2010-12-15 | — | — | EP | disclosed |
| US-20070009432-A1 | Boat tropanes | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-01-11 | — | — | US | disclosed |
| US-7105678-B2 | Boat tropanes | ORGANIX, INC. (US) | 2006-09-12 | — | — | US | disclosed |
| EP-1518562-A2 | Dopamine transporter imaging agents | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1518561-A2 | Dopamine transporter imaging agents | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-03-30 | — | — | EP | disclosed |
| US-6548041-B1 | Diagnosis, therapy of central nervous system disorders | ORGANIX, INC. | 2003-04-15 | — | — | US | disclosed |
| US-20020131931-A1 | Boat tropanes | WILMINGTON TRUST (LONDON) LIMITED, AS SECURITY AGENT (GB) | 2002-09-19 | — | — | US | disclosed |
| EP-1238978-A2 | Intermediates for the synthesis of radiolabelled tropanes | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2002-09-11 | — | — | EP | disclosed |
| US-6171576-B1 | TROPANE COMPOUND IS LINKED THROUGH THE N ATOM AT THE 8-POSITION TO A CHELATING LIGAND CAPABLE OF COMPLEXING TECHNETIUM OR RHENIUM TO PRODUCE A NEUTRAL LABELED COMPLEX THAT SELECTIVELY BINDS TO THE DOPAMINE TRANSPORTER. | ORGANIX INC. | 2001-01-09 | — | — | US | disclosed |
| EP-1051980-A2 | Dopamine transporter imaging agents | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-11-15 | — | — | EP | disclosed |
| EP-0859641-A4 | DOPAMINE TRANSPORTER IMAGING AGENT | HARVARD COLLEGE (US) | 1999-05-26 | — | — | EP | disclosed |
| EP-0859641-A1 | DOPAMINE TRANSPORTER IMAGING AGENT | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1998-08-26 | — | — | EP | disclosed |
| WO-1997016210-A1 | DOPAMINE TRANSPORTER IMAGING AGENT | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1997-05-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020131931-A1 | Boat tropanes | SLC6A3, SLC18A2, SLC6A4 | LMNA 3834/4885CYP2C9 1874/4885 |
| US-20070009432-A1 | Boat tropanes | SLC6A3, SLC18A2, SLC6A4 | LMNA 3834/4885CYP2C9 1874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.