Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | HRH1 | P35367 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29953201 | 0.75 | LMNA (0.48) | CYP2C9LMNASLC6A3SLC6A2CYP1A2 | |
| SCHEMBL9020085 | 0.75 | LMNA (0.48) | CYP2C9LMNASLC6A3SLC6A2CYP1A2 | |
| SCHEMBL3438658 | 0.74 | — | — | |
| SCHEMBL3620248 | 0.70 | CYP2C9 (0.55) | CYP2C9LMNASLC6A3SLC6A2CHRM1 | |
| SCHEMBL22266632 | 0.70 | SLC6A3 (0.44) | CYP2C9LMNASLC6A3SLC6A2SLC6A4 | |
| SCHEMBL9432467 | 0.70 | LMNA (0.48) | CYP2C9LMNASLC6A3SLC6A2CHRM1 | |
| SCHEMBL8190717 | 0.70 | LMNA (0.48) | CYP2C9LMNASLC6A3SLC6A2CHRM1 | |
| SCHEMBL709977 | 0.67 | ALDH1A1 (0.36) | — | |
| SCHEMBL17798828 | 0.67 | — | — | |
| SCHEMBL215376 | 0.67 | ALDH1A1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913726-B2 | Centrally active and orally bioavailable antidotes for organophosphate exposure and methods for making and using them | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-02-09 | — | — | US | disclosed |
| US-20190119237-A1 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-04-25 | — | — | US | disclosed |
| EP-1434604-A4 | 4-HALOETHENYLPHENYL TROPANE:SEROTONIN TRANSPORTER IMAGING AGENTS | UNIV EMORY (US) | 2008-01-09 | — | — | EP | disclosed |
| US-6843979-B2 | 4-haloethenylphenyl tropane:serotonin transporter imaging agents | EMORY UNIVERSITY (US) | 2005-01-18 | — | — | US | disclosed |
| EP-1434604-A2 | 4-HALOETHENYLPHENYL TROPANE:SEROTONIN TRANSPORTER IMAGING AGENTS | Emory University (US) | 2004-07-07 | — | — | EP | disclosed |
| WO-2003031452-A2 | 4-HALOETHENYLPHENYL TROPANE:SEROTONIN TRANSPORTER IMAGING AGENTS | EMORY UNIVERSITY (US) | 2003-04-17 | — | — | WO | disclosed |
| US-20020099184-A1 | 4-Haloethenyphenyl tropane:serotonin transporter imaging agents | ENERGY, UNITED STATES DEPARTMENT OF | 2002-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099184-A1 | 4-Haloethenyphenyl tropane:serotonin transporter imaging agents | SLC6A4, SLC6A2, SLC6A3 | CYP2C9 2067/4885LMNA 4370/4885SLC6A3 3/4885 |
| US-20190119237-A1 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM | ACHE, BCHE, IDE | CYP2C9 85/4885LMNA 3687/4885SLC6A3 615/4885 |
| US-10913726-B2 | Centrally active and orally bioavailable antidotes for organophosphate exposure and methods for making and using them | ACHE, BCHE, IDE | CYP2C9 85/4885LMNA 3687/4885SLC6A3 615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.