Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 1/20 | 0.63 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.63 |
| ▸ | CDK1 | P06493 | 1/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.63 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.63 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.63 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.63 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.63 |
| ▸ | RIOK2 | Q9BVS4 | 6/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.59 |
| ▸ | GSK3A | P49840 | 3/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.58 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.58 |
| ▸ | SNRK | Q9NRH2 | 1/20 | 0.58 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3418702 | 0.83 | CDK2 (0.57) | CCNA2CCNE1CDK2CCNA1CDK5 | |
| SCHEMBL3431712 | 0.78 | L3MBTL1 (0.61) | CCNA2CDK2CCNA1RIOK2MAPK10 | |
| SCHEMBL16126517 | 0.78 | GLS (0.50) | CDK1CCNA2CDK2CCNA1RIOK2 | |
| SCHEMBL3421534 | 0.78 | GLS (0.50) | CCNA2CDK2CCNA1MAPK8MEN1 | |
| SCHEMBL5867410 | 0.78 | CDK2 (1.00) | CCNB2CCNE2CDK1CCNB1CCNA2 | |
| SCHEMBL3424677 | 0.77 | GAA (0.57) | CCNA2CCNE1CDK2CCNA1MAPK8 | |
| SCHEMBL3421180 | 0.77 | SMN1; SMN2 (0.57) | MAPK10MEN1KMT2ANLRP3L3MBTL1 | |
| SCHEMBL2038480 | 0.76 | L3MBTL1 (0.76) | CCNA2CDK2RIOK2MAPK10GSK3A | |
| SCHEMBL3419948 | 0.76 | DEGS1 (0.57) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL25225939 | 0.76 | CDK2 (0.91) | CCNB2CCNE2CDK1CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4555547-B2 | — | — | 2010-10-06 | — | — | JP | claimed |
| JP-2004505977-A | — | — | 2004-02-26 | — | — | JP | claimed |
| EP-1320531-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-06-25 | — | — | EP | claimed |
| WO-2002012242-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2002-02-14 | — | — | WO | claimed |