Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | GAPDH | P04406 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.49 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.49 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3424677 | 0.85 | GAA (0.57) | SMN1; SMN2RAB9ANPC1GAACACNA1H | |
| SCHEMBL3418702 | 0.84 | CDK2 (0.57) | SMN1; SMN2RAB9ANPC1CACNA1GCACNA1I | |
| SCHEMBL3431712 | 0.83 | L3MBTL1 (0.61) | SMN1; SMN2RAB9ANPC1CACNA1HCACNA1G | |
| SCHEMBL22311484 | 0.80 | CCNE1 (0.48) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL22311486 | 0.79 | WNT3A (0.49) | SMN1; SMN2ALDH1A1MAPK10L3MBTL1WNT3A | |
| SCHEMBL30519019 | 0.78 | CCNE1 (0.53) | SMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL22311475 | 0.78 | CCNE1 (0.53) | SMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL3423175 | 0.77 | CCNB2 (0.63) | SMN1; SMN2MEN1KMT2AALDH1A1MAPK10 | |
| SCHEMBL30519180 | 0.77 | CCNE1 (0.56) | SMN1; SMN2ALDH1A1MAPK10L3MBTL1 | |
| SCHEMBL4421326 | 0.77 | LMNA (0.42) | RAB9AGAAKMT2APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4555547-B2 | — | — | 2010-10-06 | — | — | JP | claimed |
| JP-2004505977-A | — | — | 2004-02-26 | — | — | JP | claimed |
| EP-1320531-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-06-25 | — | — | EP | claimed |
| WO-2002012242-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2002-02-14 | — | — | WO | claimed |
| EP-1320531-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002012242-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2002-02-14 | — | — | WO | disclosed |