Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.55 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.55 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.55 |
| ▸ | GLS | O94925 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421534 | 0.84 | GLS (0.50) | L3MBTL1GLSMAPK8MEN1KMT2A | |
| SCHEMBL16126517 | 0.84 | GLS (0.50) | L3MBTL1GLSMAPK8MEN1KMT2A | |
| SCHEMBL3421180 | 0.83 | SMN1; SMN2 (0.57) | L3MBTL1CACNA1GCACNA1HCACNA1IMEN1 | |
| SCHEMBL3418702 | 0.83 | CDK2 (0.57) | CACNA1GCACNA1IGLSMEN1KMT2A | |
| SCHEMBL17402497 | 0.82 | L3MBTL1 (0.58) | L3MBTL1CACNA1GCACNA1HCACNA1IGLS | |
| SCHEMBL22311486 | 0.80 | WNT3A (0.49) | L3MBTL1MAPK8CDK2PSEN1PSEN2 | |
| SCHEMBL3423175 | 0.78 | CCNB2 (0.63) | L3MBTL1MAPK8MEN1KMT2ACCNA2 | |
| SCHEMBL30519180 | 0.78 | CCNE1 (0.56) | L3MBTL1CDK2ALDH1A1MAPK10SMN1; SMN2 | |
| SCHEMBL5867604 | 0.78 | CDK2 (0.78) | CCNA2CDK2CCNA1 | |
| SCHEMBL1947883 | 0.76 | ALDH1A1 (0.61) | L3MBTL1CACNA1GCACNA1HCACNA1IGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4555547-B2 | — | — | 2010-10-06 | — | — | JP | claimed |
| JP-2004505977-A | — | — | 2004-02-26 | — | — | JP | claimed |
| EP-1320531-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-06-25 | — | — | EP | claimed |
| WO-2002012242-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2002-02-14 | — | — | WO | claimed |
| EP-1320531-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002012242-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2002-02-14 | — | — | WO | disclosed |