Sugi Predict

Sugi Predict / Compounds / SCHEMBL342396

SCHEMBL342396

SCHEMBL342396

Cc1cccc2c1N(C(=O)CCl)CCC2

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.54
▸ DRD2 P14416 1/20 0.52
▸ DRD4 P21917 1/20 0.52
▸ ALOX12 P18054 1/20 0.51
▸ ALDH1A1 P00352 3/20 0.47
▸ CNR2 P34972 1/20 0.46
▸ MEN1 O00255 2/20 0.45
▸ KMT2A Q03164 2/20 0.45
▸ MAPT P10636 2/20 0.45
▸ LMNA P02545 1/20 0.45
▸ GAA P10253 1/20 0.45
▸ NPSR1 Q6W5P4 1/20 0.45
▸ NOTUM Q6P988 2/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ NPC1 O15118 1/20 0.41
▸ MITF O75030 1/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ NPY1R P25929 1/20 0.40
▸ NPY2R P49146 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14261668 0.87 L3MBTL1 (0.55) L3MBTL1DRD2DRD4ALOX12ALDH1A1
SCHEMBL11537014 0.84 P2RX1 (0.50) DRD2DRD4ALDH1A1MEN1KMT2A
SCHEMBL10914380 0.84 L3MBTL1 (0.57) L3MBTL1DRD2DRD4ALOX12ALDH1A1
SCHEMBL28598365 0.82 L3MBTL1 (0.59) L3MBTL1DRD2DRD4ALOX12ALDH1A1
SCHEMBL14591324 0.82 NOTUM (0.59) L3MBTL1DRD2DRD4ALOX12ALDH1A1
SCHEMBL23716019 0.78 L3MBTL1 (0.58) L3MBTL1DRD2DRD4ALOX12ALDH1A1
SCHEMBL26620270 0.78 L3MBTL1 (0.55) L3MBTL1DRD2DRD4ALOX12ALDH1A1
SCHEMBL19447114 0.78 NOTUM (0.55) L3MBTL1DRD2DRD4ALOX12ALDH1A1
SCHEMBL14263857 0.78 DRD2 (0.58) L3MBTL1DRD2DRD4ALOX12ALDH1A1
SCHEMBL342522 0.76 SMN1; SMN2 (0.68) DRD2DRD4ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170020858-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION HYDRA BIOSCIENCES INC (US) 2017-01-26 — — US disclosed
US-20170020858-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION HYDRA BIOSCIENCES INC (US) 2017-01-26 — — US disclosed
US-20170020858-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION HYDRA BIOSCIENCES INC (US) 2017-01-26 — — US disclosed
US-20160256447-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION HYDRA BIOSCIENCES INC (US) 2016-09-08 — — US disclosed
US-20160256447-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION HYDRA BIOSCIENCES INC (US) 2016-09-08 — — US disclosed
US-20160256447-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION HYDRA BIOSCIENCES INC (US) 2016-09-08 — — US disclosed
US-9181219-B2 Compounds of modulating TRPV3 function HYDRA BIOSCIENCES, INC. (US) 2015-11-10 — — US disclosed
US-9181219-B2 Compounds of modulating TRPV3 function HYDRA BIOSCIENCES, INC. (US) 2015-11-10 — — US disclosed
US-9181219-B2 Compounds of modulating TRPV3 function HYDRA BIOSCIENCES, INC. (US) 2015-11-10 — — US disclosed
US-20150299225-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION HYDRA BIOSCIENCES, INC. (US) 2015-10-22 — — US disclosed
US-20080146611-A1 Compounds for modulating TRPV3 function HYDRA BIOSCIENCES INC. (US) 2008-06-19 — — US disclosed
US-20080146611-A1 Compounds for modulating TRPV3 function HYDRA BIOSCIENCES INC. (US) 2008-06-19 — — US disclosed
US-20080146611-A1 Compounds for modulating TRPV3 function HYDRA BIOSCIENCES INC. (US) 2008-06-19 — — US disclosed
WO-2008060626-A2 COMPOUNDS FOR MODULATING TRPV3 FUNCTION HYDRA BIOSCIENCES, INC. (US) 2008-05-22 — — WO disclosed
WO-2008033564-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION HYDRA BIOSCIENCES INC. (US) 2008-03-20 — — WO disclosed
US-20070213321-A1 Compounds for modulating TRPV3 function HYDRA BIOSCIENCES, INC. (US) 2007-09-13 — — US disclosed
US-20070213321-A1 Compounds for modulating TRPV3 function HYDRA BIOSCIENCES, INC. (US) 2007-09-13 — — US disclosed
US-20070213321-A1 Compounds for modulating TRPV3 function HYDRA BIOSCIENCES, INC. (US) 2007-09-13 — — US disclosed
US-20060270688-A1 Compounds for modulating TRPV3 function HYDRA BIOSCIENCES, INC. (US) 2006-11-30 — — US disclosed
US-3997542-A 1-(Halogenated-acetyl)-1,2,3,4-tetrahydro-6-quinolinols and esters thereof STERLING DRUG INC. (US) 1976-12-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060270688-A1 Compounds for modulating TRPV3 function TRPV3, TRPV1, TRPV4 L3MBTL1 4457/4885DRD2 2349/4885DRD4 3023/4885
US-20160256447-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION TRPV3, TRPV1, TRPV4 L3MBTL1 4457/4885DRD2 2349/4885DRD4 3023/4885
US-20170020858-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION TRPV3, TRPV1, TRPV4 L3MBTL1 4457/4885DRD2 2349/4885DRD4 3023/4885
US-20150299225-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION TRPV3, TRPV1, TRPV4 L3MBTL1 4457/4885DRD2 2349/4885DRD4 3023/4885
US-20080146611-A1 Compounds for modulating TRPV3 function TRPV3, TRPV1, TRPV4 L3MBTL1 4457/4885DRD2 2349/4885DRD4 3023/4885
US-20070213321-A1 Compounds for modulating TRPV3 function TRPV3, TRPV1, TRPV4 L3MBTL1 4457/4885DRD2 2349/4885DRD4 3023/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.