Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIMP3 | P35625 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | CASP6 | P55212 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | NT5E | P21589 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 2/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2618019 | 0.83 | ALDH1A1 (0.40) | TIMP3ALDH1A1HSD17B10CASP6CYP2C9 | |
| Hydrochloric Acid SCHEMBL8634843 | 0.82 | POLB (0.50) | HSD17B10CYP2C9CA12CA2CA7 | |
| Hydrochloric Acid SCHEMBL4382156 | 0.78 | NT5E (0.46) | ALDH1A1HSD17B10CYP2C9CYP2C19TSHR | |
| Hydrochloric Acid SCHEMBL3428190 | 0.76 | L3MBTL1 (0.41) | ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3424872 | 0.75 | MYC (0.39) | ALDH1A1HSD17B10CASP6CYP2C9TSHR | |
| SCHEMBL15780352 | 0.74 | SNCA (0.39) | ALDH1A1HSD17B10CASP6CYP2C9CYP2C19 | |
| SCHEMBL27904286 | 0.74 | ALDH1A1 (0.52) | ALDH1A1HSD17B10CASP6CYP2C9CYP2C19 | |
| SCHEMBL30084548 | 0.73 | ALDH1A1 (0.48) | TIMP3ALDH1A1HSD17B10CASP6CYP2C9 | |
| SCHEMBL5409149 | 0.73 | ALDH1A1 (0.48) | TIMP3ALDH1A1HSD17B10CASP6CYP2C9 | |
| SCHEMBL8301266 | 0.72 | MYC (0.40) | ALDH1A1CASP6CYP2C9TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754273-B2 | Method of printing a time-temperature indicator based on azo coupling reactions onto a susbtrate | CIBA SPECIALTY CHEMICALS CORP. (US) | 2010-07-13 | — | — | US | disclosed |
| US-20070218206-A1 | Method of Printing a Time-Temperature Indicator Based on Azo Coupling Reactions onto a Susbtrate | CIBA SPECIALTY CHEMICALS CORP. | 2007-09-20 | — | — | US | disclosed |