Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | SENP2 | Q9HC62 | 3/20 | 0.43 |
| ▸ | SUMO2 | P61956 | 2/20 | 0.43 |
| ▸ | SUMO1 | P63165 | 2/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.43 |
| ▸ | ATIC | P31939 | 1/20 | 0.41 |
| ▸ | PHLPP2 | Q6ZVD8 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | SENP3 | Q9H4L4 | 2/20 | 0.39 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.39 |
| ▸ | CD40 | P25942 | 1/20 | 0.39 |
| ▸ | CD40LG | P29965 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3425440 | 0.82 | TIMP3 (0.40) | SENP2SUMO2SUMO1SENP7HSD17B10 | |
| SCHEMBL13317163 | 0.75 | POLB (0.56) | POLBCYP2D6SENP2SUMO2SUMO1 | |
| SCHEMBL9612276 | 0.75 | POLB (0.56) | POLBCYP2D6SENP2SUMO2SUMO1 | |
| SCHEMBL1436156 | 0.75 | SENP2 (0.60) | POLBCYP2D6SENP2SUMO2SUMO1 | |
| SCHEMBL110923 | 0.75 | SENP2 (0.60) | POLBCYP2D6SENP2SUMO2SUMO1 | |
| SCHEMBL31099405 | 0.75 | SENP2 (0.60) | POLBCYP2D6SENP2SUMO2SUMO1 | |
| SCHEMBL110924 | 0.75 | SENP2 (0.60) | POLBCYP2D6SENP2SUMO2SUMO1 | |
| SCHEMBL28560987 | 0.75 | POLB (0.83) | POLBCYP2D6SENP2SUMO2SUMO1 | |
| SCHEMBL18624977 | 0.75 | POLB (0.83) | POLBCYP2D6SENP2SUMO2SUMO1 | |
| SCHEMBL1436155 | 0.74 | SENP2 (0.59) | POLBCYP2D6SENP2SUMO2SUMO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882098-A1 | DYES CONTAINING A 2,4,5-TRIFLUORO-3,6-DICYANOPHENYL REACTIVE GROUP AND USE THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 1998-12-09 | — | — | EP | disclosed |
| US-5759247-A | COLORING PAPER, PLASTICS, TEXTILES | ZENECA LIMITED (GB) | 1998-06-02 | — | — | US | disclosed |
| WO-1997027250-A1 | DYES CONTAINING A 2,4,5-TRIFLUORO-3,6-DICYANOPHENYL REACTIVE GROUP AND USE THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 1997-07-31 | — | — | WO | disclosed |