SCHEMBL34261

SCHEMBL34261

O=C(O)C(S)CCCCC(c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 16/20 0.56
RNPEP Q9H4A4 1/20 0.47
FOLH1 Q04609 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3665671 0.85 KIF11 (0.55) KIF11RNPEPFOLH1
SCHEMBL27608746 0.81 KIF11 (0.78) KIF11
SCHEMBL4397129 0.81 KIF11 (0.78) KIF11
SCHEMBL2835140 0.80 KIF11 (0.53) KIF11
SCHEMBL6512676 0.78 KIF11 (0.53) KIF11
SCHEMBL23405871 0.77 KIF11 (0.43) KIF11
SCHEMBL17502350 0.77 KIF11 (0.53) KIF11
SCHEMBL23405873 0.77 KIF11 (0.48) KIF11
SCHEMBL8346825 0.76 KIF11 (0.60) KIF11
SCHEMBL28853106 0.75 MAPT (0.52) RNPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 202 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4736881-A2 CONTROLLED-RELEASE CNP AGONISTS WITH INCREASED NEP STABILITY Ascendis Pharma Growth Disorders A/S (DK) 2026-05-06 EP disclosed
EP-4275677-B1 DOSAGE REGIMEN FOR A CONTROLLED-RELEASE PTH COMPOUND ASCENDIS PHARMA BONE DISEASES AS (DK) 2026-04-29 EP disclosed
US-12594345-B2 Degradable hyaluronic acid hydrogels ASCENDIS PHARMA A/S (DK) 2026-04-07 US disclosed
EP-4710947-A2 CONTROLLED-RELEASE CNP AGONISTS WITH REDUCED SIDE-EFFECTS Ascendis Pharma Growth Disorders A/S (DK) 2026-03-18 EP disclosed
EP-3400065-B1 CONTROLLED-RELEASE CNP AGONISTS WITH REDUCED SIDE-EFFECTS ASCENDIS PHARMA GROWTH DISORDERS AS (DK) 2025-12-17 EP disclosed
US-12453778-B2 Incremental dose finding in controlled-release PTH compounds ASCENDIS PHARMA BONE DISEASES A/S (DK) 2025-10-28 US disclosed
US-20250302924-A1 Controlled-Release PTH Compound ASCENDIS PHARMA BONE DISEASES AS (DK) 2025-10-02 US disclosed
US-20250268988-A1 PTH Prodrugs ASCENDIS PHARMA BONE DISEASES AS (DK) 2025-08-28 US disclosed
EP-3782649-B1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2025-05-14 EP disclosed
US-12295989-B2 Controlled-release PTH compound ASCENDIS PHARMA BONE DISEASES A/S (DK) 2025-05-13 US disclosed
EP-2459228-A1 PRODRUGS COMPRISING AN INSULIN LINKER CONJUGATE Sanofi-Aventis Deutschland GmbH (DE) 2012-06-06 EP disclosed
EP-2459220-A1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS Ascendis Pharma A/S (DK) 2012-06-06 EP disclosed
EP-2459171-A1 LONG ACTING INSULIN COMPOSITION Sanofi-Aventis Deutschland GmbH (DE) 2012-06-06 EP disclosed
US-20110053848-A1 PRODRUG COMPRISING A DRUG LINKER CONJUGATE ASCENDIS PHARMA AS (DK) 2011-03-03 US disclosed
CN-101980725-A Prodrug comprising a drug linker conjugate ASCENDIS PHARMA AS 2011-02-23 CN disclosed
WO-2011012719-A1 LONG ACTING INSULIN COMPOSITION ASCENDIS PHARMA AS (DK) 2011-02-03 WO disclosed
WO-2011012718-A1 PRODRUGS COMPRISING AN INSULIN LINKER CONJUGATE ASCENDIS PHARMA AS (DK) 2011-02-03 WO disclosed
WO-2011012715-A1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2011-02-03 WO disclosed
EP-2237799-A2 PRODRUG COMPRISING A SELF-CLEAVABLE LINKER Ascendis Pharma AS (DK) 2010-10-13 EP disclosed
WO-2009095479-A2 PRODRUG COMPRISING A SELF-CLEAVABLE LINKER ASCENDIS PHARMA AS (DK) 2009-08-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250268988-A1 PTH Prodrugs PTH1R, PTMS, PHPT1 KIF11 4271/4885RNPEP 684/4885FOLH1 136/4885
US-20250302924-A1 Controlled-Release PTH Compound PTH1R, CALCA, CALCB KIF11 1861/4885RNPEP 2891/4885FOLH1 1694/4885
US-12453778-B2 Incremental dose finding in controlled-release PTH compounds PTH1R, CALCA, CALCB KIF11 2832/4885RNPEP 3372/4885FOLH1 1672/4885
US-12594345-B2 Degradable hyaluronic acid hydrogels CD44, H1-0, MMP1 KIF11 2789/4885RNPEP 1120/4885FOLH1 1979/4885
US-20110053848-A1 PRODRUG COMPRISING A DRUG LINKER CONJUGATE H1-0, H1-3, H1-2 KIF11 3244/4885RNPEP 881/4885FOLH1 642/4885
US-12295989-B2 Controlled-release PTH compound PTH1R, PTMS, FGF23 KIF11 1845/4885RNPEP 2088/4885FOLH1 748/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.