Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | TYR | P14679 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | MGLL | Q99685 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 3/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4983682 | 0.84 | ALDH1A1 (0.51) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| SCHEMBL1006628 | 0.84 | MGLL (0.66) | ALDH1A1TAS2R38HSD17B10MGLLKMT2A | |
| SCHEMBL4047674 | 0.83 | KMT2A (0.76) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| SCHEMBL3424950 | 0.82 | ALDH1A1 (0.75) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| Phenylthiourea SCHEMBL42753 | 0.81 | ALDH1A1 (1.00) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| Phenylthiourea SCHEMBL11820844 | 0.81 | ALDH1A1 (1.00) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| SCHEMBL25277661 | 0.81 | MGLL (0.61) | MGLLKDM4EPOLBCNR1SIRT2 | |
| SCHEMBL30164935 | 0.81 | MGLL (0.72) | MGLLKDM4EPOLBCNR1SIRT2 | |
| SCHEMBL4082541 | 0.81 | MGLL (0.72) | MGLLKDM4EPOLBCNR1SIRT2 | |
| SCHEMBL3976068 | 0.80 | HDAC1 (0.50) | ALDH1A1TP53TYRTSHRTAS2R38 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1849301-A | Substituted arylthiourea derivatives useful as inhibitors of viral replication | ACHILLION PHARMACEUTICALS INC (US) | 2006-10-18 | — | — | CN | claimed |
| EP-1648862-A2 | SUBSTITUTED ARYLTHIOUREA DERIVATIVES USEFUL AS INHIBITORS OF VIRAL REPLICATION | Achillion Pharmaceuticals, Inc. (US) | 2006-04-26 | — | — | EP | claimed |
| US-20050032849-A1 | Substituted arylthiourea derivatives useful as inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2005-02-10 | — | — | US | claimed |
| WO-2005007601-A2 | SUBSTITUTED ARYLTHIOUREA DERIVATIVES USEFUL AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | claimed |
| CN-105916376-A | Agrochemical composition | 农作物智力有限公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-101932630-B | Composition for resin and optical lens obtained therefrom | MITSUBISHI GAS CHEMICAL CO | 2012-12-05 | — | — | CN | disclosed |
| CN-101868563-B | Base processing agent for metal material and method for processing base for metal material | NIHON PARKERIZING | 2012-09-12 | — | — | CN | disclosed |
| CN-101535182-B | Silica-alumina composite sol and process for production thereof | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2012-02-08 | — | — | CN | disclosed |
| CN-101932630-A | Composition for resin and optical lens obtained therefrom | MITSUBISHI GAS CHEMICAL CO | 2010-12-29 | — | — | CN | disclosed |
| CN-101868563-A | Base processing agent for metal material and method for processing base for metal material | NIHON PARKERIZING | 2010-10-20 | — | — | CN | disclosed |
| US-7718671-B2 | Substituted arylthiourea derivatives useful as inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718671-B2 | Substituted arylthiourea derivatives useful as inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718671-B2 | Substituted arylthiourea derivatives useful as inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| CN-100528952-C | Accelerator system for synthetic polyisoprene latex | VANDERBILT CO R T (US) | 2009-08-19 | — | — | CN | disclosed |
| CN-1856537-A | Accelerator system for synthetic polyisoprene latex | VANDERBILT CO R T (US) | 2006-11-01 | — | — | CN | disclosed |
| US-20050032849-A1 | Substituted arylthiourea derivatives useful as inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2005-02-10 | — | — | US | disclosed |
| EP-0017484-B1 | 2-IMIDAZOLINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION OF THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-04-06 | — | — | EP | disclosed |
| EP-0017484-A1 | 2-Imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-10-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032849-A1 | Substituted arylthiourea derivatives useful as inhibitors of viral replication | TPMT, NAT1, GOT1 | ALDH1A1 261/4885TP53 2106/4885TYR 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.