Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10907764 | 0.83 | CYP3A4 (0.44) | TSHRCYP3A4L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL29790901 | 0.83 | CYP3A4 (0.50) | TSHRCYP3A4L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL1684281 | 0.83 | CYP3A4 (0.50) | TSHRCYP3A4L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL7775360 | 0.82 | TSHR (0.56) | TSHRCYP3A4L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL9324968 | 0.81 | TSHR (0.47) | TSHRCYP3A4L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL29776928 | 0.80 | ALDH1A1 (0.52) | TSHRCYP3A4L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL7775199 | 0.80 | TSHR (0.46) | TSHRCYP3A4L3MBTL1ALDH1A1KMT2A | |
| Lithium Ion SCHEMBL8330357 | 0.79 | TSHR (0.53) | TSHRCYP3A4L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL4300858 | 0.77 | ALDH1A1 (0.55) | L3MBTL1ALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL4300852 | 0.77 | ALDH1A1 (0.55) | L3MBTL1ALDH1A1KMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018148224-A1 | PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2018-08-16 | — | — | WO | claimed |
| US-20230322925-A1 | PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS | SEATTLE CHILDREN’S HOSPITAL DBA SEATTLE CHILDREN’S RES INSTITUTE (US) | 2023-10-12 | — | — | US | disclosed |
| US-20230172981-A1 | METHODS AND COMPOSITIONS FOR STIMULATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS WITH HAPTEN LABELLED CELLS | SEATTLE CHILDRENS HOSPITAL DBA SEATTLE CHILDRENS RES INST (US) | 2023-06-08 | — | — | US | disclosed |
| US-11649288-B2 | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents | SEATTLE CHILDREN'S HOSPITAL (US) | 2023-05-16 | — | — | US | disclosed |
| US-20200087399-A1 | PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS | Seattle Children's Hospital (dba Seattle Children's Research Institute) | 2020-03-19 | — | — | US | disclosed |
| WO-2018148224-A1 | PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2018-08-16 | — | — | WO | disclosed |
| US-9420780-B2 | Composition, method for producing the composition, and phytosanitary formulation containing same | RHODIA OPERATIONS (FR) | 2016-08-23 | — | — | US | disclosed |
| US-20140256554-A1 | COMPOSITION, METHOD FOR PRODUCING THE COMPOSITION, AND PHYTOSANITARY FORMULATION CONTAINING SAME | RHODIA OPERATIONS (FR) | 2014-09-11 | — | — | US | disclosed |
| US-7642379-B2 | Aminoacetonitrile derivatives and their use for controlling parasites on warm-blooded animals | NOVARTIS AG (CH) | 2010-01-05 | — | — | US | disclosed |
| US-7446219-B2 | N-acylaminoacetonitrile derivatives and their use for controlling parasites | NOVARTIS ANIMAL HEALTH US INC. (US) | 2008-11-04 | — | — | US | disclosed |
| EP-1470103-A1 | AMIDOACETONITRILE DERIVATIVES | Novartis AG (CH) | 2004-10-27 | — | — | EP | disclosed |
| EP-1456170-A1 | AMINOACETONITRILE DERIVATIVES AND THEIR USE FOR CONTROLLING PARASITES | Novartis AG (CH) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003097036-A1 | N-ACYLAMINOACETONITRILE DERIVATIVES AND THEIR USE FOR CONTROLLING PARASITES | NOVARTIS AG (CH) | 2003-11-27 | — | — | WO | disclosed |
| WO-2003080577-A2 | AMIDOACETONITRILE COMPOUNDS | NOVARTIS AG (CH) | 2003-10-02 | — | — | WO | disclosed |
| WO-2003059868-A1 | AMIDOACETONITRILE DERIVATIVES | NOVARTIS AG (CH) | 2003-07-24 | — | — | WO | disclosed |
| WO-2003048112-A1 | AMINOACETONITRILE DERIVATIVES AND THEIR USE FOR CONTROLLING PARASITES | NOVARTIS AG (CH) | 2003-06-12 | — | — | WO | disclosed |
| EP-0900024-A1 | PESTICIDAL COMPOSITIONS | Novartis AG (CH) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997040692-A1 | PESTICIDAL COMPOSITIONS | NOVARTIS AG (CH) | 1997-11-06 | — | — | WO | disclosed |
| EP-0427991-B1 | Improved pesticidal composition | SUMITOMO CHEMICAL CO (JP) | 1997-09-17 | — | — | EP | disclosed |
| US-5178872-A | PESTICIDAL COMPOSITION CONTAINING A MICROENCAPSULATED ORGANO-PHOSPHORUS OR CARBAMATE IN A PYRETHROID DISPERSION | SUMITOMO CHEMICAL CO., LTD. (JP) | 1993-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256554-A1 | COMPOSITION, METHOD FOR PRODUCING THE COMPOSITION, AND PHYTOSANITARY FORMULATION CONTAINING SAME | C1R, CNR2, SRR | TSHR 2975/4885CYP3A4 330/4885L3MBTL1 4672/4885 |
| US-11649288-B2 | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents | PHOSPHO1, LCAT, CD47 | TSHR 1224/4885CYP3A4 4045/4885L3MBTL1 1070/4885 |
| US-20230322925-A1 | PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS | PHOSPHO1, LCAT, CD47 | TSHR 1224/4885CYP3A4 4045/4885L3MBTL1 1070/4885 |
| US-20200087399-A1 | PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS | PHOSPHO1, LCAT, CD47 | TSHR 1224/4885CYP3A4 4045/4885L3MBTL1 1070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.