Sugi Predict

Sugi Predict / Compounds / SCHEMBL3428962

SCHEMBL3428962

SCHEMBL3428962

c1ccc(Nc2cccc3c2CCCC3)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 4/20 0.50
▸ KMT2A Q03164 4/20 0.50
▸ TDP1 Q9NUW8 2/20 0.50
▸ KCNK2 O95069 1/20 0.50
▸ KCNK10 P57789 1/20 0.50
▸ KCNK18 Q7Z418 1/20 0.50
▸ GAA P10253 2/20 0.49
▸ POLB P06746 2/20 0.49
▸ ALDH1A1 P00352 2/20 0.49
▸ SMN1; SMN2 Q16637 2/20 0.49
▸ HPGD P15428 1/20 0.49
▸ ATM Q13315 1/20 0.49
▸ KDM4E B2RXH2 2/20 0.48
▸ GLA P06280 1/20 0.48
▸ MAPT P10636 1/20 0.48
▸ RECQL P46063 1/20 0.48
▸ NISCH Q9Y2I1 1/20 0.48
▸ SHMT2 P34897 1/20 0.47
▸ CCR4 P51679 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30505569 1.00 MEN1 (0.50) MEN1KMT2ATDP1KCNK2KCNK10
SCHEMBL12377131 0.96 NISCH (0.51) MEN1KMT2ATDP1KCNK2KCNK10
SCHEMBL12101466 0.86 MEN1 (0.56) MEN1KMT2ATDP1KCNK2KCNK10
SCHEMBL3478127 0.84 EGFR (0.53) MEN1KMT2ATDP1KCNK2KCNK10
SCHEMBL8633085 0.84 ALDH1A1 (0.58) MEN1KMT2ATDP1KCNK2KCNK10
SCHEMBL13291666 0.83 SIRT2 (0.42) MEN1KMT2ATDP1KCNK2KCNK10
SCHEMBL19985667 0.82 BCL2L1 (0.47) MEN1KMT2AALDH1A1KDM4ENISCH
SCHEMBL4934258 0.82 SHMT2 (0.51) MEN1KMT2ATDP1KCNK2KCNK10
SCHEMBL21625850 0.81 RAPGEF4 (0.47) MEN1KMT2ATDP1KCNK2KCNK10
SCHEMBL21625844 0.80 CCR4 (0.53) MEN1KMT2ATDP1KCNK2KCNK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111372938-B Polycyclic compound and organic light emitting device including the same 株式会社LG化学 2023-08-08 — — CN disclosed
US-20200407658-A1 ALKYLATED ALKOXYDIARYLAMINE ANTIOXIDANTS LANXESS SOLUTIONS US INC. (US) 2020-12-31 — — US disclosed
US-10808197-B2 Alkylated alkoxydiarylamine antioxidants LANXESS SOLUTIONS US INC. (US) 2020-10-20 — — US disclosed
CN-111372938-A Polycyclic compound and organic light emitting device including the same 株式会社LG化学 2020-07-03 — — CN disclosed
WO-2020017931-A1 POLYCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME 주식회사 엘지화학 2020-01-23 — — WO disclosed
WO-2018057365-A1 ALKYLATED ALKOXYDIARYLAMINE ANTIOXIDANTS LANXESS SOLUTIONS US INC. (US) 2018-03-29 — — WO disclosed
US-20180079984-A1 ALKYLATED ALKOXYDIARYLAMINE ANTIOXIDANTS LANXESS CORPORATION 2018-03-22 — — US disclosed
US-20180079984-A1 ALKYLATED ALKOXYDIARYLAMINE ANTIOXIDANTS LANXESS CORPORATION 2018-03-22 — — US disclosed
US-8637706-B2 Nuclear receptor binding agents GTX, INC. (US) 2014-01-28 — — US disclosed
US-20120157539-A1 NUCLEAR RECEPTOR BINDING AGENTS GTX, INC. 2012-06-21 — — US disclosed
US-8158828-B2 Nuclear receptor binding agents GTX, INC. (US) 2012-04-17 — — US disclosed
EP-1645552-B1 Electroluminescent devices made with double-spiro organic compounds LG CHEMICAL LTD (KR) 2010-05-05 — — EP disclosed
US-20090062341-A1 Nuclear receptor binding agents GTX, INC 2009-03-05 — — US disclosed
US-20070265296-A1 Nuclear receptor binding agents GTX, INC. 2007-11-15 — — US disclosed
EP-0709364-B1 Tetrahydronaphthylaminostyrene compounds and their use in electrophotographic photoreceptors HODOGAYA CHEMICAL CO LTD (JP) 1999-04-21 — — EP disclosed
US-5721082-A HIGH SENSITIVITY, DURABILITY HODOGAYA CHEMICAL CO., LTD. (JP) 1998-02-24 — — US disclosed
US-5654481-A Amine compound HODOGAYA CHEMICAL CO., LTD. (JP) 1997-08-05 — — US disclosed
EP-0709364-A1 Tetrahydronaphthylaminostyrene compounds and their use in electrophotographic photoreceptors HODOGAYA CHEMICAL CO LTD (JP) 1996-05-01 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10808197-B2 Alkylated alkoxydiarylamine antioxidants GPX4, CAT, SOD1 MEN1 4755/4885KMT2A 1818/4885TDP1 494/4885
US-20070265296-A1 Nuclear receptor binding agents GPER1, ESRRG, ESR2 MEN1 1408/4885KMT2A 1506/4885TDP1 3158/4885
US-20200407658-A1 ALKYLATED ALKOXYDIARYLAMINE ANTIOXIDANTS GPX4, CAT, SOD1 MEN1 4755/4885KMT2A 1818/4885TDP1 494/4885
US-20090062341-A1 Nuclear receptor binding agents GPER1, ESRRG, ESR2 MEN1 1408/4885KMT2A 1506/4885TDP1 3158/4885
US-20120157539-A1 NUCLEAR RECEPTOR BINDING AGENTS GPER1, ESRRG, ESR2 MEN1 1408/4885KMT2A 1506/4885TDP1 3158/4885
US-20180079984-A1 ALKYLATED ALKOXYDIARYLAMINE ANTIOXIDANTS GPX4, CAT, SOD1 MEN1 4755/4885KMT2A 1818/4885TDP1 494/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.