Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 8/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 9/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL344025 | 1.00 | NR3C1 (0.35) | NR3C1MAPK1CRHR1CRHR2CNR2 | |
| SCHEMBL342889 | 0.79 | MITF (0.38) | NR3C1CRHR1 | |
| SCHEMBL342887 | 0.79 | MITF (0.38) | NR3C1CRHR1 | |
| SCHEMBL343334 | 0.79 | AURKA (0.41) | — | |
| SCHEMBL28651973 | 0.78 | GRM2 (0.34) | NR3C1CRHR1 | |
| SCHEMBL342531 | 0.78 | CDK4 (0.46) | — | |
| SCHEMBL342955 | 0.78 | CDK1 (0.39) | — | |
| SCHEMBL342899 | 0.77 | CRHR1 (0.33) | NR3C1MAPK1CRHR1 | |
| SCHEMBL343114 | 0.77 | CRHR1 (0.33) | NR3C1MAPK1CRHR1 | |
| SCHEMBL342898 | 0.77 | CRHR1 (0.33) | NR3C1MAPK1CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | CHUK, MAP2K2, CDK3 | NR3C1 642/4885MAPK1 7/4885CRHR1 1832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.