Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 18/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | DLK1 | P80370 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3432392 | 0.81 | MAP3K12 (0.52) | MAP3K12 | |
| SCHEMBL21658973 | 0.80 | MAP3K12 (0.48) | MAP3K12DLK1 | |
| SCHEMBL3430566 | 0.78 | CHRNA7 (0.57) | LMNA | |
| SCHEMBL3433512 | 0.78 | CHRNB2 (0.51) | MAP3K12LMNA | |
| SCHEMBL3431236 | 0.73 | LMNA (0.42) | LMNA | |
| SCHEMBL2577774 | 0.71 | MAP3K12 (0.49) | MAP3K12 | |
| SCHEMBL18436556 | 0.68 | PRKDC (0.45) | MAP3K12 | |
| SCHEMBL16210488 | 0.68 | MAP3K12 (1.00) | MAP3K12 | |
| SCHEMBL18335242 | 0.68 | DHFR (0.56) | LMNA | |
| SCHEMBL23124346 | 0.67 | MAP3K12 (0.41) | MAP3K12DLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265607-A1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | Rigel Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009103032-A1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | RIGEL PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |