Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | FABP3 | P05413 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3432487 | 1.00 | KDM4E (0.45) | KDM4EFABP3FABP4TRPM4RAB9A | |
| SCHEMBL13880845 | 0.77 | RECQL (0.47) | RAB9AL3MBTL1HPGDNPC1MEN1 | |
| SCHEMBL1903512 | 0.76 | KDM4E (0.50) | KDM4EFABP3FABP4TRPM4RAB9A | |
| SCHEMBL16318050 | 0.73 | KDM4E (0.54) | KDM4EFABP3FABP4TRPM4RAB9A | |
| SCHEMBL11923473 | 0.73 | TRPM4 (0.58) | KDM4EFABP3FABP4TRPM4RAB9A | |
| SCHEMBL8009873 | 0.72 | KDM4E (0.54) | KDM4EFABP3FABP4TRPM4L3MBTL1 | |
| SCHEMBL4607469 | 0.71 | KDM4E (0.49) | KDM4EFABP3FABP4TRPM4RAB9A | |
| SCHEMBL10489654 | 0.71 | ALDH1A1 (0.57) | KDM4ETRPM4RAB9AHPGDNPC1 | |
| SCHEMBL6497268 | 0.71 | ITGB3 (0.53) | KDM4EFABP3FABP4TRPM4MEN1 | |
| SCHEMBL2624008 | 0.70 | HPGD (0.63) | KDM4EFABP3FABP4TRPM4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063802-A1 | 3, 4-DI-SUBSTITUTED CYCLOBUTENE- 1, 2 -DIONES AS CXCR2 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2010-06-10 | — | — | WO | disclosed |