Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | SCD | O00767 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27737305 | 0.80 | RAB9A (0.60) | RAB9ANPC1AURKAPIM1CDK2 | |
| SCHEMBL3430947 | 0.80 | NPC1 (0.44) | RAB9ANPC1CYP1A2SMN1; SMN2LMNA | |
| SCHEMBL3426753 | 0.79 | MEN1 (0.54) | RAB9ANPC1SMN1; SMN2KMT2ATP53 | |
| SCHEMBL11412643 | 0.78 | RAB9A (0.57) | RAB9ANPC1AURKAPIM1CDK2 | |
| SCHEMBL3430925 | 0.77 | MEN1 (0.44) | RAB9ANPC1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL3430002 | 0.76 | TAAR1 (0.51) | SMN1; SMN2LMNAKMT2AMEN1POLB | |
| SCHEMBL3429605 | 0.74 | NPC1 (0.56) | RAB9ANPC1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL5810260 | 0.74 | NPC1 (0.52) | RAB9ANPC1AURKAPIM1CDK2 | |
| SCHEMBL6688096 | 0.73 | HPGD (0.49) | RAB9ANPC1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL6918568 | 0.72 | MEN1 (0.59) | RAB9ANPC1SCDSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252296-A1 | 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | Wyeth LLC (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009091788-A1 | 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-07-23 | — | — | WO | disclosed |