Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3426753 | 0.81 | MEN1 (0.54) | HPGDALDH1A1RAB9ANPC1PKM | |
| SCHEMBL3430002 | 0.78 | TAAR1 (0.51) | ALDH1A1POLBLMNAKMT2AMEN1 | |
| SCHEMBL3427447 | 0.76 | GRM5 (0.49) | RAB9ANPC1KMT2AMEN1KDM4E | |
| SCHEMBL3429605 | 0.76 | NPC1 (0.56) | HPGDALDH1A1RAB9ANPC1LMNA | |
| SCHEMBL16518677 | 0.74 | RAB9A (0.56) | HPGDALDH1A1RAB9ANPC1POLB | |
| SCHEMBL3430947 | 0.74 | NPC1 (0.44) | HPGDALDH1A1RAB9ANPC1LMNA | |
| SCHEMBL3430925 | 0.74 | MEN1 (0.44) | HPGDRAB9ANPC1PKMKMT2A | |
| SCHEMBL7982157 | 0.74 | NPSR1 (0.47) | ALDH1A1RAB9ANPC1POLBKMT2A | |
| SCHEMBL19031886 | 0.73 | NPSR1 (0.49) | ALDH1A1RAB9ANPC1POLBKMT2A | |
| SCHEMBL3434055 | 0.73 | RAB9A (0.52) | HPGDALDH1A1RAB9ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487841-A1 | THIOPYRIMIDINE AND ISOTHIAZOLOPYRIMIDINE KINASE INHIBITORS | Abbott Laboratories (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080625-A1 | THIOPYRIMIDINE AND ISOTHIAZOLOPYRIMIDINE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2003-10-02 | — | — | WO | disclosed |