Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.44 |
| ▸ | MMP2 | P08253 | 5/20 | 0.43 |
| ▸ | MMP9 | P14780 | 4/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433509 | 0.88 | OTUD7B (0.48) | ABL1CES1SCN9AADAMTS5 | |
| SCHEMBL1897022 | 0.70 | GRIA1 (0.60) | CES1NOTUMKIF11 | |
| SCHEMBL22314930 | 0.70 | CES1 (0.64) | ABL1CES1 | |
| SCHEMBL2264074 | 0.70 | CES1 (0.51) | CES1ADAMTS5 | |
| SCHEMBL14499205 | 0.69 | PGR (0.42) | CA9 | |
| SCHEMBL3310995 | 0.69 | KIF11 (0.70) | CES1KIF11 | |
| SCHEMBL7170898 | 0.68 | CSNK1G1 (0.45) | ADAMTS5CA12CA9 | |
| SCHEMBL3596379 | 0.68 | MGAT2 (0.37) | — | |
| SCHEMBL13717944 | 0.68 | ABL1 (0.52) | ABL1CA12CA9 | |
| SCHEMBL941821 | 0.68 | MMP2 (0.49) | MMP2MMP9MMP8SCN9ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053757-A1 | 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL | GILEAD PALO ALTO, INC. (US) | 2010-05-14 | — | — | WO | claimed |