SCHEMBL343535

SCHEMBL343535

O=C(Cl)c1cc(F)ccc1F

nearest known ligand 0.68

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CES2 O00748 6/20 0.68
CES1 P23141 6/20 0.68
ALDH1A1 P00352 1/20 0.56
ALOX15 P16050 1/20 0.56
KEAP1 Q14145 1/20 0.45
CA3 P07451 1/20 0.44
CA6 P23280 1/20 0.44
CA5A P35218 1/20 0.44
CA9 Q16790 1/20 0.44
CA14 Q9ULX7 1/20 0.44
CA5B Q9Y2D0 1/20 0.44
MDM2 Q00987 6/20 0.44
TAS1R3 Q7RTX0 2/20 0.40
TAS1R1 Q7RTX1 2/20 0.40
TAS1R2 Q8TE23 2/20 0.40
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methylene Chloride SCHEMBL28312143 0.94 CES2 (0.61) CES2CES1ALDH1A1ALOX15KEAP1
SCHEMBL8676977 0.87 CES2 (0.53) CES2CES1ALDH1A1ALOX15KEAP1
SCHEMBL9834572 0.84 CES2 (0.52) CES2CES1ALDH1A1ALOX15KEAP1
SCHEMBL284068 0.82 ALDH1A1 (0.56) CES2CES1ALDH1A1ALOX15TAS1R3
SCHEMBL30349584 0.82 ALDH1A1 (0.56) CES2CES1ALDH1A1ALOX15TAS1R3
SCHEMBL165619 0.82 CES2 (0.68) CES2CES1ALDH1A1ALOX15KEAP1
SCHEMBL28304570 0.82 CES2 (0.47) CES2CES1ALDH1A1ALOX15MDM2
SCHEMBL27673772 0.81 CES2 (0.74) CES2CES1ALDH1A1KEAP1CA3
SCHEMBL3180092 0.81 CES2 (1.00) CES2CES1KEAP1CA3CA6
SCHEMBL11669995 0.80 ALDH1A1 (0.54) CES2CES1ALDH1A1ALOX15MDM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 698 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630503-B2 Method for producing benzopyranone compound and novel intermediate used therein ILAB (KR) 2026-05-19 US claimed
WO-2024250573-A1 REVERSE OSMOSIS MEMBRANE PREPARATION METHOD AND REVERSE OSMOSIS MEMBRANE PREPARED THEREBY 沃顿科技股份有限公司 2024-12-12 WO claimed
CN-119098067-A Method for producing reverse osmosis membrane and reverse osmosis membrane produced thereby 沃顿科技股份有限公司 2024-12-10 CN claimed
CN-115427385-B Process for producing benzopyrone compound and novel intermediate therefor 艾伊莱布 2024-03-01 CN claimed
CN-116891443-B Isoindol-1-one derivative and preparation method and application thereof 潍坊医学院 2023-12-01 CN claimed
US-20230150928-A1 METHOD FOR PRODUCING BENZOPYRANONE COMPOUND AND NOVEL INTERMEDIATE USED THEREIN ILAB (KR) 2023-05-18 US claimed
EP-4140979-A1 METHOD FOR PRODUCING BENZOPYRANONE COMPOUND AND NOVEL INTERMEDIATE USED THEREIN ILAB (KR) 2023-03-01 EP claimed
CN-115427385-A Process for producing benzopyranone compound and novel intermediate therefor 艾伊莱布 2022-12-02 CN claimed
CN-114432900-A Preparation method of anti-pollution composite reverse osmosis membrane and anti-pollution composite reverse osmosis membrane prepared by same 沃顿科技股份有限公司 2022-05-06 CN claimed
CN-113773264-A Pyrimidine amide compound applied to herbicide and preparation method thereof 池州飞昊达化工有限公司 2021-12-10 CN claimed
WO-2021215900-A1 METHOD FOR PRODUCING BENZOPYRANONE COMPOUND AND NOVEL INTERMEDIATE USED THEREIN (주)아이랩 (KR) 2021-10-28 WO claimed
CN-112358414-A Unnatural amino acids and their use in protein site-directed modification and protein interactions 中国科学院上海药物研究所 2021-02-12 CN claimed
US-12630503-B2 Method for producing benzopyranone compound and novel intermediate used therein ILAB (KR) 2026-05-19 US disclosed
CN-122010796-A Small molecule inhibitor based on lactate dehydrogenase targeting design and application thereof 南京师范大学 2026-05-12 CN disclosed
EP-4713018-A1 TRANSFECTION COMPOSITIONS SUITABLE FOR PRODUCING A BIOLOGICAL PRODUCT PolyPlus Transfection (FR) 2026-03-25 EP disclosed
EP-3699174-B1 COMPOSITION FOR PREVENTING OR TREATING TNF-RELATED DISEASES, CONTAINING DERIVATIVE AS ACTIVE INGREDIENT, AND METHOD FOR INHIBITING TNF ACTIVITY BY USING SAME ILAB (KR) 2025-11-12 EP disclosed
US-4728662-A DIURETICS, URICOSURICS, HYPOTENSIVES HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1988-03-01 US disclosed
US-4673746-A DIURETICS, HYPOTENSIVES HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1987-06-16 US disclosed
EP-0002666-B1 1,2-BENZISOXAZOLYLOXY (OR THIO) ACETIC ACIDS AND RELATED COMPOUNDS, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM HOECHST AKTIENGESELLSCHAFT (DE) 1982-02-17 EP disclosed
EP-0002666-A1 1,2-Benzisoxazolyloxy (or thio) acetic acids and related compounds, process for their preparation and medicines containing them HOECHST AKTIENGESELLSCHAFT (DE) 1979-07-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150928-A1 METHOD FOR PRODUCING BENZOPYRANONE COMPOUND AND NOVEL INTERMEDIATE USED THEREIN CYP51A1, CYP1B1, CBR1 CES2 731/4885CES1 362/4885ALDH1A1 98/4885
US-12630503-B2 Method for producing benzopyranone compound and novel intermediate used therein TNF, NFKBIA, TNFRSF1A CES2 3925/4885CES1 1208/4885ALDH1A1 524/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.