SCHEMBL165619

SCHEMBL165619

O=C(Cl)c1ccc(F)cc1F

nearest known ligand 0.68

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.68
CES1 P23141 3/20 0.68
ALDH1A1 P00352 1/20 0.56
ALOX15 P16050 1/20 0.56
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
SNCA P37840 1/20 0.44
KDM4E B2RXH2 1/20 0.41
KEAP1 Q14145 1/20 0.41
HTT P42858 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7621298 0.89 CES2 (0.55) CES2CES1ALDH1A1ALOX15NPC1
SCHEMBL8591371 0.87 CES2 (0.53) CES2CES1ALDH1A1ALOX15NPC1
SCHEMBL9834572 0.84 CES2 (0.52) CES2CES1ALDH1A1ALOX15NPC1
SCHEMBL343535 0.82 CES2 (0.68) CES2CES1ALDH1A1ALOX15NPC1
SCHEMBL14136792 0.82 CES2 (0.47) CES2CES1ALDH1A1ALOX15NPC1
SCHEMBL8070666 0.81 CES2 (1.00) CES2CES1NPC1RAB9AL3MBTL1
SCHEMBL13291390 0.81 CES2 (0.74) CES2CES1NPC1RAB9AL3MBTL1
SCHEMBL4957103 0.80 ALDH1A1 (0.54) CES2CES1ALDH1A1ALOX15RAB9A
SCHEMBL9627405 0.80 ALDH1A1 (0.54) CES2CES1ALDH1A1ALOX15HTT
SCHEMBL645757 0.80 ALDH1A1 (0.54) CES2CES1ALDH1A1ALOX15NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1314 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117919939-A Solvent-resistant nanofiltration membrane for separating nonpolar solvent system, and preparation and application thereof 烟台大学 2024-04-26 CN claimed
CN-116891443-B Isoindol-1-one derivative and preparation method and application thereof 潍坊医学院 2023-12-01 CN claimed
CN-114751900-B D-A type organic luminescent material and preparation method and application thereof 南京邮电大学 2023-09-12 CN claimed
CN-115703648-A Modified zinc oxide, preparation method thereof and light-emitting diode TCL科技集团股份有限公司 2023-02-17 CN claimed
CN-114751900-A D-A type organic luminescent material and preparation method and application thereof 南京邮电大学 2022-07-15 CN claimed
CN-113773264-A Pyrimidine amide compound applied to herbicide and preparation method thereof 池州飞昊达化工有限公司 2021-12-10 CN claimed
CN-108484577-B Pyrimidine-quinolone heterozygote and preparation method and application thereof 复旦大学 2021-03-30 CN claimed
CN-108947868-B Preparation process of 2, 4-difluorobenzonitrile 山东师范大学 2021-02-23 CN claimed
CN-109651354-A - 4 (1H) qualone derivative of 3- (2-[4-morpholinodithio base) and its preparation method and application 广西师范大学 2019-04-19 CN claimed
CN-108947868-A The preparation process of one kind 2,4- difluorobenzonilyile 山东师范大学 2018-12-07 CN claimed
EP-1506176-B1 AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM PFIZER ITALIA SRL (IT) 2013-04-24 EP claimed
EP-1089988-A4 FLUOROPHENYL RESIN COMPOUNDS AVENTIS PHARM PROD INC (US) 2005-01-19 EP claimed
US-6639023-B1 Such as 4-hydroxy, sulfonic acid or sulfonyl chloride-2,3,5,6-tetrafluorobenzamidomethyl-polystyrene resin; solid phase synthesis AVENTIS PHARMACEUTICALS INC. 2003-10-28 US claimed
EP-1089988-A1 FLUOROPHENYL RESIN COMPOUNDS Aventis Pharmaceuticals Products Inc. (US) 2001-04-11 EP claimed
WO-1999067228-A1 FLUOROPHENYL RESIN COMPOUNDS AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 1999-12-29 WO claimed
EP-4387957-B1 FUNGICIDAL SUBSTITUTED HETEROCYCLES FMC CORP (US) 2026-04-29 EP disclosed
EP-4713018-A1 TRANSFECTION COMPOSITIONS SUITABLE FOR PRODUCING A BIOLOGICAL PRODUCT PolyPlus Transfection (FR) 2026-03-25 EP disclosed
EP-0002666-A1 1,2-Benzisoxazolyloxy (or thio) acetic acids and related compounds, process for their preparation and medicines containing them HOECHST AKTIENGESELLSCHAFT (DE) 1979-07-11 EP disclosed
US-4160862-A ANTIINFLAMMATORY STERLING DRUG INC. (US) 1979-07-10 US disclosed
US-4021431-A ANTIINFLAMMATORY AGENTS STERLING DRUG INC. (US) 1977-05-03 US disclosed