Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10477955 | 0.95 | PGR (0.38) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL9648799 | 0.85 | ESR1 (0.38) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL18489316 | 0.84 | ESR1 (0.35) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL7531500 | 0.80 | PGR (0.42) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL9345533 | 0.77 | LMNA (0.35) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL9006813 | 0.74 | SLC6A3 (0.36) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL11103919 | 0.71 | HCAR2 (0.34) | KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL18982990 | 0.71 | SLC6A3 (0.45) | SLC6A2SLC6A3 | |
| SCHEMBL27578460 | 0.71 | — | — | |
| SCHEMBL29288035 | 0.70 | PGR (0.40) | ESR1PGRCHRM2ADORA3AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041918-A1 | CYCLOPENTENE DIOL MONOACETATE DERIVATIVES | NOVARTIS AG | 2010-02-18 | — | — | US | disclosed |
| US-20100041918-A1 | CYCLOPENTENE DIOL MONOACETATE DERIVATIVES | NOVARTIS AG | 2010-02-18 | — | — | US | disclosed |
| CN-101553459-A | Cyclopentene diol monoacetate derivatives | NOVARTIS AG (CH) | 2009-10-07 | — | — | CN | disclosed |
| EP-2084121-A1 | CYCLOPENTENE DIOL MONOACETATE DERIVATIVES | Novartis AG (CH) | 2009-08-05 | — | — | EP | disclosed |
| EP-2084121-A1 | CYCLOPENTENE DIOL MONOACETATE DERIVATIVES | Novartis AG (CH) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008055874-A1 | CYCLOPENTENE DIOL MONOACETATE DERIVATIVES | NOVARTIS AG (CH) | 2008-05-15 | — | — | WO | disclosed |
| WO-2008055874-A1 | CYCLOPENTENE DIOL MONOACETATE DERIVATIVES | NOVARTIS AG (CH) | 2008-05-15 | — | — | WO | disclosed |
| US-5091431-A | Hypotensive agents | SCHERING CORPORATION (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0330004-A1 | Nucleoside-type compounds as phosphodiesterase inhibitors | SCHERING CORPORATION (US) | 1989-08-30 | — | — | EP | disclosed |
| WO-1989007102-A1 | NULCEOSIDETYPE COMPOUNDS WHICH ARE PHOSPHODIESTERASE INHIBITORS | SCHERING CORPORATION (US) | 1989-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041918-A1 | CYCLOPENTENE DIOL MONOACETATE DERIVATIVES | ADH1A, CYP1B1, CYP1A2 | ESR1 1419/4885PGR 1079/4885CHRM2 1276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.